| The Impact of MIR137 on Dorsolateral Prefrontal-Hippocampal Functional Connectivity in Healthy Subjects | |
Liu, Bing1,2 ; Zhang, Xiaolong1; Hou, Bing1,2; Li, Jin1,2; Qiu, Chengxiang1; Qin, Wen3; Yu, Chunshui3; Jiang, Tianzi1,2,4,5
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| 发表期刊 | NEUROPSYCHOPHARMACOLOGY
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| 2014-08-01 | |
| 卷号 | 39期号:9页码:2153-2160 |
| 文章类型 | Article |
| 摘要 | A recent mega-analysis combining genome-wide association study data revealed that a variant of microRNA 137 (MIR137) exhibits the most significant association with schizophrenia. Other biological evidence also consistently suggests that MIR137 may have a pivotal role in the pathogenesis of schizophrenia. However, the underlying neural mechanism remains unclear. As the disrupted dorsolateral prefrontal cortex (DLPFC) coupling with the hippocampal formation (HF) has been widely observed in schizophrenia patients, DLPFC-HF dysconnectivity can therefore be thought of as a pivotal intermediate phenotype that links genetic variants of psychiatric risk genes to schizophrenia. This study used resting-state functional magnetic resonance imaging to test whether the MIR137 variant (rs1625579) impacts DLPFC-HF functional connectivity and cognitive performance in 290 young, healthy Han Chinese individuals. To identify functional connectivity between DLPFC and HF, a seed-based functional connectivity analysis was used. The association between DLPFC-HF connectivity and working memory performance was further examined in individuals with different MIR137 genotypes. The individuals who are homozygous for the MIR137 risk allele (TT), which confers a high risk for schizophrenia, exhibited significantly different DLPFC-HF functional connectivity compared with TG individuals. Moreover, the DLPFC-HF connectivity could predict the working memory performance in MIR137 TG individuals, but not in TT individuals. The current findings obtained in a large sample of healthy participants identified potential neural mechanisms linking MIR137 with the risk of developing schizophrenia via the intermediate phenotype of DLPFC-HF connectivity. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 关键词[WOS] | WORKING-MEMORY PERFORMANCE ; ANTI-CORRELATED NETWORKS ; RESTING-STATE ; HUMAN BRAIN ; ANATOMICAL CONNECTIVITY ; PSYCHOSIS VARIANT ; GENETIC RISK ; SCHIZOPHRENIA ; MICRORNA ; MIR-137 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
| WOS类目 | Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
| WOS记录号 | WOS:000339177800012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/3169 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 4.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia 5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China |
| 第一作者单位 | 中国科学院自动化研究所; 模式识别国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu, Bing,Zhang, Xiaolong,Hou, Bing,et al. The Impact of MIR137 on Dorsolateral Prefrontal-Hippocampal Functional Connectivity in Healthy Subjects[J]. NEUROPSYCHOPHARMACOLOGY,2014,39(9):2153-2160. |
| APA | Liu, Bing.,Zhang, Xiaolong.,Hou, Bing.,Li, Jin.,Qiu, Chengxiang.,...&Jiang, Tianzi.(2014).The Impact of MIR137 on Dorsolateral Prefrontal-Hippocampal Functional Connectivity in Healthy Subjects.NEUROPSYCHOPHARMACOLOGY,39(9),2153-2160. |
| MLA | Liu, Bing,et al."The Impact of MIR137 on Dorsolateral Prefrontal-Hippocampal Functional Connectivity in Healthy Subjects".NEUROPSYCHOPHARMACOLOGY 39.9(2014):2153-2160. |
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