Altered Spontaneous Activity in Anisometropic Amblyopia Subjects: Revealed by Resting-State fMRI

	Altered Spontaneous Activity in Anisometropic Amblyopia Subjects: Revealed by Resting-State fMRI
	Lin, Xiaoming 1; Ding, Kun 1; Liu, Yong2 ; Yan, Xiaohe 1; Song, Shaojie 1; Jiang, Tianzi2,3,4
发表期刊	PLOS ONE
	2012-08-24
卷号	7 期号:8
文章类型	Article
摘要	Amblyopia, also known as lazy eye, usually occurs during early childhood and results in poor or blurred vision. Recent neuroimaging studies have found cortical structural/functional abnormalities in amblyopia. However, until now, it was still not known whether the spontaneous activity of the brain changes in amblyopia subjects. In the present study, regional homogeneity (ReHo), a measure of the homogeneity of functional magnetic resonance imaging signals, was used for the first time to investigate changes in resting-state local spontaneous brain activity in individuals with anisometropic amblyopia. Compared with age-and gender-matched subjects with normal vision, the anisometropic amblyopia subjects showed decreased ReHo of spontaneous brain activity in the right precuneus, the left medial prefrontal cortex, the left inferior frontal gyrus, and the left cerebellum, and increased ReHo of spontaneous brain activity was found in the bilateral conjunction area of the postcentral and precentral gyri, the left paracentral lobule, the left superior temporal gyrus, the left fusiform gyrus, the conjunction area of the right insula, putamen and the right middle occipital gyrus. The observed decreases in ReHo may reflect decreased visuo-motor processing ability, and the increases in ReHo in the somatosensory cortices, the motor areas and the auditory area may indicate compensatory plasticity in amblyopia.
WOS标题词	Science & Technology
关键词[WOS]	TRANSCRANIAL MAGNETIC STIMULATION ; DIFFUSION TENSOR TRACTOGRAPHY ; POSITRON-EMISSION-TOMOGRAPHY ; REGIONAL HOMOGENEITY CHANGES ; LATERAL GENICULATE-NUCLEUS ; VERGENCE EYE-MOVEMENTS ; ABNORMAL VISUAL-CORTEX ; FUNCTIONAL CONNECTIVITY ; EARLY BLINDNESS ; BRAIN ACTIVITY
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000308225500045
引用统计	被引频次：40[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3180
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Sun Yat Sen Univ, State Key Lab Ophthalmol, Zhongshan Ophthalm Ctr, Guangzhou 510275, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing, Peoples R China 3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 4.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
推荐引用方式 GB/T 7714	Lin, Xiaoming,Ding, Kun,Liu, Yong,et al. Altered Spontaneous Activity in Anisometropic Amblyopia Subjects: Revealed by Resting-State fMRI[J]. PLOS ONE,2012,7(8).
APA	Lin, Xiaoming,Ding, Kun,Liu, Yong,Yan, Xiaohe,Song, Shaojie,&Jiang, Tianzi.(2012).Altered Spontaneous Activity in Anisometropic Amblyopia Subjects: Revealed by Resting-State fMRI.PLOS ONE,7(8).
MLA	Lin, Xiaoming,et al."Altered Spontaneous Activity in Anisometropic Amblyopia Subjects: Revealed by Resting-State fMRI".PLOS ONE 7.8(2012).