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Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI
Zang Yu-Feng; He Yong; Zhu Chao-Zhe; Cao Qing-Jiu; Sui Man-Qiu; Liang Meng; Tian Li-Xia; Jiang Tian-Zi; Wang, Yu-Feng
Source PublicationBRAIN & DEVELOPMENT
2007-03-01
Volume29Issue:2Pages:83-91
SubtypeArticle
AbstractIn children with attention deficit hyperactivity disorder (ADHD), functional neuroimaging studies have revealed abnormalities in various brain regions, including prefrontal-striatal circuit, cerebellum, and brainstem. In the current study, we used a new marker of functional magnetic resonance imaging (fMRI), amplitude of low-frequency (0.01-0.08 Hz) fluctuation (ALFF) to investigate the baseline brain function of this disorder. Thirteen boys with ADHD (13.0 +/- 1.4 years) were examined by resting-state fMRI and compared with age-matched controls. As a result, we found that patients with ADHD had decreased ALFF in the right inferior frontal cortex, left sensorimotor cortex, and bilateral cerebellum and the vermis as well as increased ALFF in the right anterior cingulated cortex, left sensorimotor cortex, and bilateral brainstem. This resting-state fMRI study suggests that the changed spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology in children with ADHD. (c) 2006 Elsevier B.V. All rights reserved.
KeywordAttention Deficit Hyperactivity Disorder Resting-state Functional Mri Amplitude Low-frequency Fluctuation Spontaneous Neuronal Activity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordDEFICIT HYPERACTIVITY DISORDER ; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; CEREBRAL-BLOOD-FLOW ; EVENT-RELATED FMRI ; MAGNETIC-RESONANCE ; RESPONSE-INHIBITION ; DEFAULT-MODE ; METHYLPHENIDATE ; CONNECTIVITY ; BOYS
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology
WOS IDWOS:000244380400005
Citation statistics
Cited Times:902[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3189
Collection脑网络组研究中心
Affiliation1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100871, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zang Yu-Feng,He Yong,Zhu Chao-Zhe,et al. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI[J]. BRAIN & DEVELOPMENT,2007,29(2):83-91.
APA Zang Yu-Feng.,He Yong.,Zhu Chao-Zhe.,Cao Qing-Jiu.,Sui Man-Qiu.,...&Wang, Yu-Feng.(2007).Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI.BRAIN & DEVELOPMENT,29(2),83-91.
MLA Zang Yu-Feng,et al."Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI".BRAIN & DEVELOPMENT 29.2(2007):83-91.
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