Altered Functional Connectivity of the Marginal Division in Alzheimer's Disease

	Altered Functional Connectivity of the Marginal Division in Alzheimer's Disease
	Zhang, Zengqiang 1,4; Liu, Yong2,3 ; Zhou, Bo 1; Zheng, Jinlong 5; Yao, Hongxiang 6; An, Ningyu 6; Wang, Pan 1; Guo, Yan'e 1; Dai, Haitao 4; Wang, Luning 1; Shu, Siyun 7; Zhang, Xi 1; Jiang, Tianzi2,3,8
发表期刊	CURRENT ALZHEIMER RESEARCH
	2014-02-01
卷号	11 期号:2 页码:145-155
文章类型	Article
摘要	The marginal division (MrD) is a neostriatum subregion that links the limbic system and basal nucleus of Meynert; it is an important subcortical center that is involved in learning and memory. Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia in the elderly. AD clinically manifests as gradually progressive cognitive decline with behavioral disorders. Prior to full dementia, AD patients typically experience a transient state, i.e., mild cognitive impairment (MCI). Amnestic MCI individuals, but not all MCI individuals, frequently convert to AD dementia. To specify whether and how the functional relationships between the MrD and other brain regions change during AD, functional connectivity was assessed using resting-state functional MRI data and associated neuropsychological tests in AD and MCI patients (amnestic-type). Compared with normal controls, a different decreased functional connectivity pattern was observed between the MrD and caudate, the amygdala/parahippocampal region, the inferior frontal gyrus, the superior temporal gyrus, and the cerebellum for AD/MCI patients. Moreover, the functional connectivity between the MrD and the identified regions was significantly correlated with the neuropsychological scores among the MCI and AD subjects. Our results suggest that the MrD functional network is disrupted during AD.
关键词	Alzheimer's Disease Functional Connectivity Marginal Division Mild Cognitive Impairment Resting-state Fmri
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	MILD COGNITIVE IMPAIRMENT ; RESTING-STATE FMRI ; LONG-TERM POTENTIATION ; POSTERIOR CINGULATE CORTEX ; HUMAN AMYGDALA ; DISCONNECTION SYNDROME ; REGIONAL HOMOGENEITY ; EMOTIONAL FACES ; CAUDATE-NUCLEUS ; LIMBIC SYSTEM
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Clinical Neurology ; Neurosciences
WOS记录号	WOS:000333195900006
引用统计	被引频次：20[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3196
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Chinese Peoples Liberat Army Gen Hosp, Inst Gerontol & Geriatr, Dept Neurol, Beijing 100853, Peoples R China 2.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 4.Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Sanya 572014, Peoples R China 5.Xuzhou Med Coll, Dept Neurol, Huaian Hosp 2, Huaian 223002, Peoples R China 6.Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing 100853, Peoples R China 7.Southern Med Univ, ZhuJiang Hosp, Dept Pediat, Guangzhou 510280, Guangdong, Peoples R China 8.Univ Elect Sci & Technol China, Key Lab NeuroInformat, Sch Life Sci & Technol, Minist Educ, Chengdu 610054, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zengqiang,Liu, Yong,Zhou, Bo,et al. Altered Functional Connectivity of the Marginal Division in Alzheimer's Disease[J]. CURRENT ALZHEIMER RESEARCH,2014,11(2):145-155.
APA	Zhang, Zengqiang.,Liu, Yong.,Zhou, Bo.,Zheng, Jinlong.,Yao, Hongxiang.,...&Jiang, Tianzi.(2014).Altered Functional Connectivity of the Marginal Division in Alzheimer's Disease.CURRENT ALZHEIMER RESEARCH,11(2),145-155.
MLA	Zhang, Zengqiang,et al."Altered Functional Connectivity of the Marginal Division in Alzheimer's Disease".CURRENT ALZHEIMER RESEARCH 11.2(2014):145-155.