Decreased functional connectivity of the amygdala in Alzheimer's disease revealed by resting-state fMRI

	Decreased functional connectivity of the amygdala in Alzheimer's disease revealed by resting-state fMRI
	Yao, Hongxiang 1; Liu, Yong2,3 ; Zhou, Bo 4; Zhang, Zengqiang 4; An, Ningyu 1; Wang, Pan 4; Wang, Luning 4; Zhang, Xi 4; Jiang, Tianzi2,3,5,6
发表期刊	EUROPEAN JOURNAL OF RADIOLOGY
	2013-09-01
卷号	82 期号:9 页码:1531-1538
文章类型	Article
摘要	Alzheimer's disease (AD), the most common cause of dementia, is thought to be a progressive neurodegenerative disease that is clinically characterised by a decline of memory and other cognitive functions. Mild cognitive impairment (MCI) is considered to be the prodromal stage of AD. However, the relationship between AD and MCI and the development process remains unclear. The amygdala is one of the most vulnerable structures in the early stages of AD. To our knowledge, this is the first report on the alteration of the functional connectivity of the amygdala in AD and MCI subjects. We hypothesised that the amygdala-cortical loop is impaired in AD and that these alterations relate to the disease severity. In our study, we used resting-state functional MRIs to investigate the altered amygdala connectivity patterns in 35 AD patients, 27 MCI patients and 27 age- and gender-matched normal controls (NC). Compared with the NC, the decreased functional connectivity found in the AD patients was mainly located between the amygdala and the regions that are included in the default mode, context conditioning and extinction networks. Importantly, the decreased functional connectivity between the amygdala and some of the identified regions was positively correlated with MMSE, which indicated that the cognitive function impairment is related to an altered functional connectivity pattern (C) 2013 Elsevier Ireland Ltd. All rights reserved.
关键词	Amygdala Resting State Fmri Alzheimer's Disease Mild Cognitive Impairment
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	MILD COGNITIVE IMPAIRMENT ; DEFAULT-MODE NETWORK ; EMOTIONAL MEMORY ; QUANTITATIVE METAANALYSIS ; REGIONAL HOMOGENEITY ; PREFRONTAL CORTEX ; HEAD MOTION ; HIPPOCAMPUS ; EXTINCTION ; RELEVANCE
收录类别	SCI
语种	英语
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000323935200042
引用统计	被引频次：70[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3198
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing 100853, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 4.Chinese Peoples Liberat Army Gen Hosp, Inst Gerontol & Geriatr, Dept Neurol, Beijing 100853, Peoples R China 5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
推荐引用方式 GB/T 7714	Yao, Hongxiang,Liu, Yong,Zhou, Bo,et al. Decreased functional connectivity of the amygdala in Alzheimer's disease revealed by resting-state fMRI[J]. EUROPEAN JOURNAL OF RADIOLOGY,2013,82(9):1531-1538.
APA	Yao, Hongxiang.,Liu, Yong.,Zhou, Bo.,Zhang, Zengqiang.,An, Ningyu.,...&Jiang, Tianzi.(2013).Decreased functional connectivity of the amygdala in Alzheimer's disease revealed by resting-state fMRI.EUROPEAN JOURNAL OF RADIOLOGY,82(9),1531-1538.
MLA	Yao, Hongxiang,et al."Decreased functional connectivity of the amygdala in Alzheimer's disease revealed by resting-state fMRI".EUROPEAN JOURNAL OF RADIOLOGY 82.9(2013):1531-1538.