Altered White Matter Integrity in the Congenital and Late Blind People | |
Wang, Dawei1; Qin, Wen1; Liu, Yong2,3; Zhang, Yunting1; Jiang, Tianzi2,3; Yu, Chunshui1 | |
发表期刊 | NEURAL PLASTICITY |
2013 | |
文章类型 | Article |
摘要 | The blind subjects have experienced a series of brain structural and functional alterations due to the visual deprivation. It remains unclear as to whether white matter changes differ between blind subjects with visual deprivation before and after a critical developmental period. The present study offered a direct comparison in changes of white matter fractional anisotropy (FA) between congenital blind (CB) and late blind (LB) individuals. Twenty CB, 21 LB (blindness onset after 18 years old), and 40 sight control (SC) subjects were recruited. Both the tract-based spatial statistics (TBSS) and voxel-based analysis (VBA) showed lower FA in the bilateral optic radiations in both blind groups, suggesting that the loss of white matter integrity was the prominent hallmark in the blind people. The LB group showed more extensive white matter impairment than the CB group, indicating the mechanisms of white matter FA changes are different between the CB and LB groups. Using a loose threshold, a trend of an increased FA was found in the bilateral corticospinal tracts in the LB but with a smaller spatial extent relative to the CB. These results suggest that white matter FA changes in the blind subjects are the reflection of multiple mechanisms, including the axonal degeneration, deafferentation, and plasticity. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
关键词[WOS] | VOXEL-BASED MORPHOMETRY ; VISUAL-CORTEX ; NEUROMYELITIS-OPTICA ; ADAPTIVE-CHANGES ; HUMAN BRAIN ; DIFFUSION ; FMRI ; ACTIVATION ; PLASTICITY ; HUMANS |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000318078600001 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/3212 |
专题 | 脑网络组研究 |
作者单位 | 1.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Dawei,Qin, Wen,Liu, Yong,et al. Altered White Matter Integrity in the Congenital and Late Blind People[J]. NEURAL PLASTICITY,2013. |
APA | Wang, Dawei,Qin, Wen,Liu, Yong,Zhang, Yunting,Jiang, Tianzi,&Yu, Chunshui.(2013).Altered White Matter Integrity in the Congenital and Late Blind People.NEURAL PLASTICITY. |
MLA | Wang, Dawei,et al."Altered White Matter Integrity in the Congenital and Late Blind People".NEURAL PLASTICITY (2013). |
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