CASIA OpenIR  > 脑网络组研究
Altered White Matter Integrity in the Congenital and Late Blind People
Wang, Dawei1; Qin, Wen1; Liu, Yong2,3; Zhang, Yunting1; Jiang, Tianzi2,3; Yu, Chunshui1
发表期刊NEURAL PLASTICITY
2013
文章类型Article
摘要The blind subjects have experienced a series of brain structural and functional alterations due to the visual deprivation. It remains unclear as to whether white matter changes differ between blind subjects with visual deprivation before and after a critical developmental period. The present study offered a direct comparison in changes of white matter fractional anisotropy (FA) between congenital blind (CB) and late blind (LB) individuals. Twenty CB, 21 LB (blindness onset after 18 years old), and 40 sight control (SC) subjects were recruited. Both the tract-based spatial statistics (TBSS) and voxel-based analysis (VBA) showed lower FA in the bilateral optic radiations in both blind groups, suggesting that the loss of white matter integrity was the prominent hallmark in the blind people. The LB group showed more extensive white matter impairment than the CB group, indicating the mechanisms of white matter FA changes are different between the CB and LB groups. Using a loose threshold, a trend of an increased FA was found in the bilateral corticospinal tracts in the LB but with a smaller spatial extent relative to the CB. These results suggest that white matter FA changes in the blind subjects are the reflection of multiple mechanisms, including the axonal degeneration, deafferentation, and plasticity.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]VOXEL-BASED MORPHOMETRY ; VISUAL-CORTEX ; NEUROMYELITIS-OPTICA ; ADAPTIVE-CHANGES ; HUMAN BRAIN ; DIFFUSION ; FMRI ; ACTIVATION ; PLASTICITY ; HUMANS
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000318078600001
引用统计
被引频次:65[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/3212
专题脑网络组研究
作者单位1.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Wang, Dawei,Qin, Wen,Liu, Yong,et al. Altered White Matter Integrity in the Congenital and Late Blind People[J]. NEURAL PLASTICITY,2013.
APA Wang, Dawei,Qin, Wen,Liu, Yong,Zhang, Yunting,Jiang, Tianzi,&Yu, Chunshui.(2013).Altered White Matter Integrity in the Congenital and Late Blind People.NEURAL PLASTICITY.
MLA Wang, Dawei,et al."Altered White Matter Integrity in the Congenital and Late Blind People".NEURAL PLASTICITY (2013).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Dawei]的文章
[Qin, Wen]的文章
[Liu, Yong]的文章
百度学术
百度学术中相似的文章
[Wang, Dawei]的文章
[Qin, Wen]的文章
[Liu, Yong]的文章
必应学术
必应学术中相似的文章
[Wang, Dawei]的文章
[Qin, Wen]的文章
[Liu, Yong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。