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The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala
Long, Haixia1; Liu, Bing1; Hou, Bing1; Wang, Chao2; Li, Jin1; Qin, Wen3; Wang, Dawei3; Zhou, Yuan4; Kendrick, Keith M.2; Yu, Chunshui3; Jiang, Tianzi1,2,5
Source PublicationNEUROSCIENCE BULLETIN
2013-02-01
Volume29Issue:1Pages:4-15
SubtypeArticle
AbstractThe short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and multi-modal MRI approaches in a large group of healthy Han Chinese participants (n = 233). In contrast to findings in Caucasians, we found that long-allele (L) carriers had higher anxiety scores. In another group (n = 64) experiencing significant levels of depression or anxiety, the L-allele frequency was also significantly higher. In healthy participants, L-carriers had reduced functional and anatomical connectivity between the amygdala and prefrontal cortex (PFC), which was correlated with anxiety or depression scores. Our findings demonstrated that in Chinese Han participants, in contrast to Caucasians, the L-allele confers vulnerability to anxiety or depression and weakens top-down emotional control between the PFC and amygdala. Therefore, ethnic background should be taken into account in generelated studies and their potential clinical applications.
Keyword5-httlpr Functional And Anatomical Connectivity Amygdala Prefrontal Cortex Han Chinese
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordSEROTONIN TRANSPORTER GENE ; MAJOR DEPRESSIVE DISORDER ; ANTIDEPRESSANT RESPONSE ; FUNCTIONAL POLYMORPHISM ; EMOTION PERCEPTION ; REGULATORY REGION ; ASSOCIATION ; NEUROBIOLOGY ; FLUVOXAMINE ; POPULATION
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000314298300003
Citation statistics
Cited Times:40[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3216
Collection脑网络组研究中心
Affiliation1.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
2.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China
3.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
First Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Long, Haixia,Liu, Bing,Hou, Bing,et al. The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala[J]. NEUROSCIENCE BULLETIN,2013,29(1):4-15.
APA Long, Haixia.,Liu, Bing.,Hou, Bing.,Wang, Chao.,Li, Jin.,...&Jiang, Tianzi.(2013).The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala.NEUROSCIENCE BULLETIN,29(1),4-15.
MLA Long, Haixia,et al."The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala".NEUROSCIENCE BULLETIN 29.1(2013):4-15.
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