Abnormal topological organization of structural brain networks in schizophrenia

	Abnormal topological organization of structural brain networks in schizophrenia
	Zhang, Yuanchao 1,2; Lin, Lei 2,8; Lin, Ching-Po 3,4; Zhou, Yuan5 ; Chou, Kun-Hsien 3; Lo, Chun-Yi 3,4; Su, Tung-Ping 6,7; Jiang, Tianzi1,2,9
发表期刊	SCHIZOPHRENIA RESEARCH
	2012-11-01
卷号	141 期号:2-3 页码:109-118
文章类型	Article
摘要	Schizophrenia is a debilitating mental disorder characterized by disturbances of thought and emotion as well as neurocognitive deficits. It is hypothesized that the core symptoms of schizophrenia arise from the inability to integrate neural processes segregated across distributed brain regions. Graph theory allows us to verify this hypothesis at large-scale structural network level. In this study, a sample of 101 schizophrenic patients and 101 healthy controls was included. We sought to investigate the abnormality of network topological organization in patients with schizophrenia by using the cortical thickness measurement from magnetic resonance imaging. Brain networks were constructed by thresholding cortical thickness correlation matrices of 78 regions and analyzed using graph theoretical approaches. Compared to healthy controls, patients showed increased characteristic path length and clustering coefficient in the structural cortical networks. Moreover, schizophrenia patients were associated with reduced nodal centrality in several regions of the default network and increased nodal centrality mainly in primary cortex and paralimbic cortex regions. These findings suggest that the structural networks of schizophrenic patients have a less optimal topological organization, resulting in reduced capacity to integrate information across brain regions. (C) 2012 Elsevier B.V. All rights reserved.
关键词	Schizophrenia Structural Network Cortical Thickness Topological Organization Betweenness Centrality
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	SMALL-WORLD NETWORKS ; HUMAN CEREBRAL-CORTEX ; MAGNETIC-RESONANCE IMAGES ; SURFACE-BASED ANALYSIS ; CORTICAL THICKNESS ; FUNCTIONAL CONNECTIVITY ; 1ST-EPISODE SCHIZOPHRENIA ; ANATOMICAL CONNECTIVITY ; COGNITIVE DYSMETRIA ; ONSET SCHIZOPHRENIA
收录类别	SCI ; SSCI
语种	英语
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000309511300001
引用统计	被引频次：102[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3226
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China 3.Natl Yang Ming Univ, Inst Neurosci, Brain Connect Lab, Taipei 112, Taiwan 4.Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei 112, Taiwan 5.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100190, Peoples R China 6.Taipei Vet Gen Hosp, Dept Psychiat, Taipei 112, Taiwan 7.Natl Yang Ming Univ, Coll Med, Dept Psychiat, Taipei 112, Taiwan 8.Zhejiang Univ, Dept Math, Hangzhou 310027, Peoples R China 9.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Zhang, Yuanchao,Lin, Lei,Lin, Ching-Po,et al. Abnormal topological organization of structural brain networks in schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2012,141(2-3):109-118.
APA	Zhang, Yuanchao.,Lin, Lei.,Lin, Ching-Po.,Zhou, Yuan.,Chou, Kun-Hsien.,...&Jiang, Tianzi.(2012).Abnormal topological organization of structural brain networks in schizophrenia.SCHIZOPHRENIA RESEARCH,141(2-3),109-118.
MLA	Zhang, Yuanchao,et al."Abnormal topological organization of structural brain networks in schizophrenia".SCHIZOPHRENIA RESEARCH 141.2-3(2012):109-118.