Cortical thickness analysis and optimized voxel-based morphometry in children and adolescents with prelingually profound sensorineural hearing loss
Li, Jianhong1; Li, Wenjing2; Xian, Junfang1; Li, Yong1; Liu, Zhaohui1; Liu, Sha3; Wang, Xiaocui3; Wang, Zhenchang1; He, Huiguang2
Source PublicationBRAIN RESEARCH
2012-01-09
Volume1430Pages:35-42
SubtypeArticle
AbstractCrossmodal neuroplastic changes following auditory deprivation in individuals with profound sensorineural hearing loss (SNHL) have been well documented in previous literature. However, previous studies have shown very little evidence of structural brain changes in individuals with prelingually profound SNHL and no studies have reported significant differences of gray matter (GM) in deaf subjects. Therefore, it is essential to employ a more specific and sensitive technique to detect subtle structural brain differences in deaf individuals. The objective of our study was to investigate neuroanatomical differences in children and adolescents with profound SNHL by cortical thickness analysis and optimized voxel-based morphometry (VBM). T1-weighted volumetric images of 16 children and adolescents with prelingually profound SNHL and 16 hearing controls were analyzed. The ANCOVA analysis revealed a statistically significant decreased average cortical thickness of the whole brain. As to vertex-based analysis, cortical thickness of the deaf subjects showed significant thinning in the left precentral gyms, right postcentral gyms, the left superior occipital gyrus and the left fusiform gyrus compared with the hearing subjects. VBM revealed statistically significant focal reduction of white matter (WM) volume in the left middle frontal gyms and the right inferior occipital gyrus in deaf subjects without statistically significant differences in GM volume between the two groups. These findings demonstrated that structural changes happened not only in the WM but also in the GM of the subjects with prelingually profound SNHL, which have never been reported before in any previous literature. Our results also implicated the potential neuroplastic changes associated with crossmodal reorganization in the brain after auditory deprivation in the early deafness. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
KeywordChildren And Adolescents Neuroplasticity Sensorineural Hearing Loss Cortical Thickness Optimized Voxel-based Morphomety
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordAUTOMATED 3-D EXTRACTION ; AUDITORY-CORTEX ; SIGN-LANGUAGE ; BRAIN-REGIONS ; COCHLEAR IMPLANTS ; MRI DATA ; DEAF ; DYSLEXIA ; CHINESE ; REGISTRATION
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000300534000005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3740
Collection复杂系统管理与控制国家重点实验室_影像分析与机器视觉
Affiliation1.Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing 100730, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Complex Syst & Intelligence Sci, Beijing 100190, Peoples R China
3.Capital Med Univ, Beijing Tongren Hosp, Beijing Inst Otolaryngol, Beijing 100005, Peoples R China
Recommended Citation
GB/T 7714
Li, Jianhong,Li, Wenjing,Xian, Junfang,et al. Cortical thickness analysis and optimized voxel-based morphometry in children and adolescents with prelingually profound sensorineural hearing loss[J]. BRAIN RESEARCH,2012,1430:35-42.
APA Li, Jianhong.,Li, Wenjing.,Xian, Junfang.,Li, Yong.,Liu, Zhaohui.,...&He, Huiguang.(2012).Cortical thickness analysis and optimized voxel-based morphometry in children and adolescents with prelingually profound sensorineural hearing loss.BRAIN RESEARCH,1430,35-42.
MLA Li, Jianhong,et al."Cortical thickness analysis and optimized voxel-based morphometry in children and adolescents with prelingually profound sensorineural hearing loss".BRAIN RESEARCH 1430(2012):35-42.
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