Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Metal-Organic Frameworks as a Theranostic Nanoplatform for Combinatorial Chemophotothermal Therapy Adapted to Different Administration | |
Shang, Wenting1,2; Peng, Li3; Guo, Pengyu3; Hui, Hui1,2; Yang, Xin1,2; Tian, Jie1,2,4 | |
发表期刊 | ACS BIOMATERIALS SCIENCE & ENGINEERING |
ISSN | 2373-9878 |
2020-02-01 | |
卷号 | 6期号:2页码:1008-1016 |
摘要 | With the rapid development of nanotechnology, nanomaterial drug delivery systems have provided an alternative for designing controllable drug delivery systems due to their spatiotemporally controllable properties. As a new type of porous material, metal organic frameworks (MOFs) have been widely used in biomedical applications, especially drug delivery systems, owing to their tunable pore size, high surface area and pore volume, and easy surface modification. Here, we demonstrate an MOF as a theranostic nanoplatform to combine drug therapy and phototherapy after labeling targeting peptide iRGD. The micropore Fe-MOF was used as MRI agents for locating tumors and as nanocarriers to upload chemotherapeutic drugs. Moreover, MOF showed excellent targeting performance under different administration including intravenous injection for breast cancer and local instillation for bladder cancer. Notably, when irradiated with an 808 nm laser, the agent demonstrates the high efficacy of photothermal therapy and heat release efficiency of the drug around the tumor site. This combination therapy provides an alternative drug administration method and can be adapted to a series of cancer cell types and molecular targets associated with disease progression. |
关键词 | metal-organic frameworks (MOFs) intravenous injection local instillation photothermal therapy combination therapy |
DOI | 10.1021/acsbiomaterials.9b01075 |
关键词[WOS] | DELIVERY SYSTEMS ; DRUG ; CANCER ; CONJUGATE ; DIAGNOSIS ; DESIGN ; AGENTS |
收录类别 | SCI |
语种 | 英语 |
资助项目 | CAS[XDBS01030200] ; National Key R&D Program of China[2017YFA0205203] ; Chinese Academy of Sciences[YJKYYQ20170075] ; National Key R&D Program of China[2017YFA0700401] ; National Key R&D Program of China[2016YFC0103803] ; Chinese Academy of Sciences[GJJSTD20170004] ; National Natural Science Foundation of China[81671851] ; National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81671851] ; Chinese Academy of Sciences[GJJSTD20170004] ; National Key R&D Program of China[2016YFC0103803] ; National Key R&D Program of China[2017YFA0700401] ; Chinese Academy of Sciences[YJKYYQ20170075] ; National Key R&D Program of China[2017YFA0205203] ; CAS[XDBS01030200] |
WOS研究方向 | Materials Science |
WOS类目 | Materials Science, Biomaterials |
WOS记录号 | WOS:000513086900021 |
出版者 | AMER CHEMICAL SOC |
七大方向——子方向分类 | 其他 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/38356 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Hui, Hui; Yang, Xin; Tian, Jie |
作者单位 | 1.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Harbin Med Univ, Hosp 4, Urinary Surg Dept, Haerbin 150001, Peoples R China 4.Beihang Univ, Sch Med, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing 100191, Peoples R China |
第一作者单位 | 中国科学院自动化研究所; 中国科学院分子影像重点实验室 |
通讯作者单位 | 中国科学院自动化研究所; 中国科学院分子影像重点实验室 |
推荐引用方式 GB/T 7714 | Shang, Wenting,Peng, Li,Guo, Pengyu,et al. Metal-Organic Frameworks as a Theranostic Nanoplatform for Combinatorial Chemophotothermal Therapy Adapted to Different Administration[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020,6(2):1008-1016. |
APA | Shang, Wenting,Peng, Li,Guo, Pengyu,Hui, Hui,Yang, Xin,&Tian, Jie.(2020).Metal-Organic Frameworks as a Theranostic Nanoplatform for Combinatorial Chemophotothermal Therapy Adapted to Different Administration.ACS BIOMATERIALS SCIENCE & ENGINEERING,6(2),1008-1016. |
MLA | Shang, Wenting,et al."Metal-Organic Frameworks as a Theranostic Nanoplatform for Combinatorial Chemophotothermal Therapy Adapted to Different Administration".ACS BIOMATERIALS SCIENCE & ENGINEERING 6.2(2020):1008-1016. |
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