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Metal-Organic Frameworks as a Theranostic Nanoplatform for Combinatorial Chemophotothermal Therapy Adapted to Different Administration
Shang, Wenting1,2; Peng, Li3; Guo, Pengyu3; Hui, Hui1,2; Yang, Xin1,2; Tian, Jie1,2,4
Source PublicationACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN2373-9878
2020-02-01
Volume6Issue:2Pages:1008-1016
Abstract

With the rapid development of nanotechnology, nanomaterial drug delivery systems have provided an alternative for designing controllable drug delivery systems due to their spatiotemporally controllable properties. As a new type of porous material, metal organic frameworks (MOFs) have been widely used in biomedical applications, especially drug delivery systems, owing to their tunable pore size, high surface area and pore volume, and easy surface modification. Here, we demonstrate an MOF as a theranostic nanoplatform to combine drug therapy and phototherapy after labeling targeting peptide iRGD. The micropore Fe-MOF was used as MRI agents for locating tumors and as nanocarriers to upload chemotherapeutic drugs. Moreover, MOF showed excellent targeting performance under different administration including intravenous injection for breast cancer and local instillation for bladder cancer. Notably, when irradiated with an 808 nm laser, the agent demonstrates the high efficacy of photothermal therapy and heat release efficiency of the drug around the tumor site. This combination therapy provides an alternative drug administration method and can be adapted to a series of cancer cell types and molecular targets associated with disease progression.

Keywordmetal-organic frameworks (MOFs) intravenous injection local instillation photothermal therapy combination therapy
DOI10.1021/acsbiomaterials.9b01075
WOS KeywordDELIVERY SYSTEMS ; DRUG ; CANCER ; CONJUGATE ; DIAGNOSIS ; DESIGN ; AGENTS
Indexed BySCI
Language英语
Funding ProjectCAS[XDBS01030200] ; National Key R&D Program of China[2017YFA0205203] ; Chinese Academy of Sciences[YJKYYQ20170075] ; National Key R&D Program of China[2017YFA0700401] ; National Key R&D Program of China[2016YFC0103803] ; Chinese Academy of Sciences[GJJSTD20170004] ; National Natural Science Foundation of China[81671851] ; National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81671851] ; Chinese Academy of Sciences[GJJSTD20170004] ; National Key R&D Program of China[2016YFC0103803] ; National Key R&D Program of China[2017YFA0700401] ; Chinese Academy of Sciences[YJKYYQ20170075] ; National Key R&D Program of China[2017YFA0205203] ; CAS[XDBS01030200]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000513086900021
PublisherAMER CHEMICAL SOC
Sub direction classification其他
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/38356
Collection中国科学院分子影像重点实验室
Corresponding AuthorHui, Hui; Yang, Xin; Tian, Jie
Affiliation1.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Harbin Med Univ, Hosp 4, Urinary Surg Dept, Haerbin 150001, Peoples R China
4.Beihang Univ, Sch Med, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing 100191, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences;  Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences;  Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Shang, Wenting,Peng, Li,Guo, Pengyu,et al. Metal-Organic Frameworks as a Theranostic Nanoplatform for Combinatorial Chemophotothermal Therapy Adapted to Different Administration[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020,6(2):1008-1016.
APA Shang, Wenting,Peng, Li,Guo, Pengyu,Hui, Hui,Yang, Xin,&Tian, Jie.(2020).Metal-Organic Frameworks as a Theranostic Nanoplatform for Combinatorial Chemophotothermal Therapy Adapted to Different Administration.ACS BIOMATERIALS SCIENCE & ENGINEERING,6(2),1008-1016.
MLA Shang, Wenting,et al."Metal-Organic Frameworks as a Theranostic Nanoplatform for Combinatorial Chemophotothermal Therapy Adapted to Different Administration".ACS BIOMATERIALS SCIENCE & ENGINEERING 6.2(2020):1008-1016.
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