Selective intra-arterial brain cooling improves long-term outcomes in a non-human primate model of embolic stroke: Efficacy depending on reperfusion status

doi:10.1177/0271678X20903697

	Selective intra-arterial brain cooling improves long-term outcomes in a non-human primate model of embolic stroke: Efficacy depending on reperfusion status
	Wu, Di 1,2,3,4; Chen, Jian 5; Hussain, Mohammed 6; Wu, Longfei 1,2,3; Shi, Jingfei 1,2; Wu, Chuanjie 1,2,3; Ma, Yanhui 7; Zhang, Mo 8; Yang, Qi 8; Fu, Yongjuan 9; Duan, Yunxia 1,2; Ma, Cui 10; Yan, Feng 1,2; Zhu, Zixin 1,2; He, Xiaoduo 1,2; Yao, Tianqi 1,2; Song, Ming10 ; Zhi, Xinglong 5; Wang, Chunxiu 1,2; Cai, Lipeng 1,2; Li, Chuanhui 1,2; Li, Shengli 1,2; Zhang, Yongbiao 11; Ding, Yuchuan 1,2,6; Ji, Xunming 1,2,3,4
发表期刊	JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
ISSN	0271-678X
	2020-03-03
页码	12
通讯作者	Ji, Xunming(jixm@ccmu.edu.cn)
摘要	Nearly all stroke neuroprotection modalities, including selective intra-arterial cooling (SI-AC), have failed to be translated from bench to bed side. Potentially overlooked reasons may be biological gaps, inadequate attention to reperfusion states and mismatched attention to neurological benefits. To advance stroke translation, we describe a novel thrombus-based stroke model in adult rhesus macaques. Intra-arterial thrombolysis with tissue plasminogen activator leads to three clinically relevant outcomes - complete, partial, and no recanalization based on digital subtraction angiography. We also find reperfusion as a prerequisite for SI-AC-induced benefits, in which models with complete or partial reperfusion exhibit significantly reduced infarct volumes, mitigated neurological deficits, improved upper limb motor dysfunction in both acute and chronic stages; however, no further neuroprotection is observed in those without reperfusion. In summary, we discover reperfusion as a crucial regulator of SI-AC-induced neuroprotection and provide insights of long-term functional benefits in behavior and imaging levels. Our findings could be important not only for the translational prerequisite and potential molecular targets, but also for this thrombus-thrombolysis model in monkeys as a powerful tool for further translational stroke studies.
关键词	Middle cerebral artery occlusion hypothermia rhesus monkey tissue plasminogen activator reperfusion
DOI	10.1177/0271678X20903697
关键词[WOS]	ACUTE ISCHEMIC-STROKE ; ENDOVASCULAR THROMBECTOMY ; INTRAVENOUS THROMBOLYSIS ; CEREBRAL-ISCHEMIA ; HYPOTHERMIA ; NEUROPROTECTION ; OCCLUSION ; INFUSION ; UPDATE ; TRIAL
收录类别	SCI
语种	英语
资助项目	Chang Jiang Scholars Program from the Chinese Ministry of Education[T2014251] ; National Natural Science Foundation of China for Outstanding Youth[81325007] ; National Natural Science Foundation of China[81620108011] ; National Natural Science Foundation of China[81871022] ; National Natural Science Foundation of China[81771260] ; National Key R&D Program of China[2017YFC1308401] ; mission talent project of Beijing Municipal Administration of Hospitals[SML20150802] ; Beijing Municipal Administration of Hospitals' Youth Programme[QML20170802] ; Chang Jiang Scholars Program from the Chinese Ministry of Education[T2014251] ; National Natural Science Foundation of China for Outstanding Youth[81325007] ; National Natural Science Foundation of China[81620108011] ; National Natural Science Foundation of China[81871022] ; National Natural Science Foundation of China[81771260] ; National Key R&D Program of China[2017YFC1308401] ; mission talent project of Beijing Municipal Administration of Hospitals[SML20150802] ; Beijing Municipal Administration of Hospitals' Youth Programme[QML20170802]
项目资助者	Chang Jiang Scholars Program from the Chinese Ministry of Education ; National Natural Science Foundation of China for Outstanding Youth ; National Natural Science Foundation of China ; National Key R&D Program of China ; mission talent project of Beijing Municipal Administration of Hospitals ; Beijing Municipal Administration of Hospitals' Youth Programme
WOS研究方向	Endocrinology & Metabolism ; Hematology ; Neurosciences & Neurology
WOS类目	Endocrinology & Metabolism ; Hematology ; Neurosciences
WOS记录号	WOS:000517872900001
出版者	SAGE PUBLICATIONS INC
引用统计	被引频次：28[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/38443
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Ji, Xunming
作者单位	1.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China 2.Capital Med Univ, Xuanwu Hosp, China Amer Inst Neurosci, Beijing 100053, Peoples R China 3.Beijing Key Lab Hypoxia Conditioning Translat Med, Beijing, Peoples R China 4.Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China 5.Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China 6.Wayne State Univ, Sch Med, Dept Neurosurg, Detroit, MI USA 7.Capital Med Univ, Xuanwu Hosp, Dept Anesthesiol, Beijing, Peoples R China 8.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China 9.Capital Med Univ, Xuanwu Hosp, Dept Pathol, Beijing, Peoples R China 10.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Interdisciplinary Innovat Inst Med & Engn, Sch Biol Sci & Med Engn, Beijing, Peoples R China 11.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wu, Di,Chen, Jian,Hussain, Mohammed,et al. Selective intra-arterial brain cooling improves long-term outcomes in a non-human primate model of embolic stroke: Efficacy depending on reperfusion status[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,2020:12.
APA	Wu, Di.,Chen, Jian.,Hussain, Mohammed.,Wu, Longfei.,Shi, Jingfei.,...&Ji, Xunming.(2020).Selective intra-arterial brain cooling improves long-term outcomes in a non-human primate model of embolic stroke: Efficacy depending on reperfusion status.JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,12.
MLA	Wu, Di,et al."Selective intra-arterial brain cooling improves long-term outcomes in a non-human primate model of embolic stroke: Efficacy depending on reperfusion status".JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020):12.