Alteration of Neural Activity in The Sensorimotor and Visual Cortices and Vigilance Level During Sleep Deprivation

doi:10.16476/j.pibb.2019.0055

CASIA OpenIR > 模式识别国家重点实验室

	Alteration of Neural Activity in The Sensorimotor and Visual Cortices and Vigilance Level During Sleep Deprivation
	Zhang Dai1,2 ; Zuo Zhen-Tao 3,4,5; Rao Heng-Yi 6; Fan Yong 7
发表期刊	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN	1000-3282
	2020-02-01
卷号	47 期号:2 页码:139-156
通讯作者	Zuo Zhen-Tao(ztzuo@bcslab.ibp.ac.cn) ; Fan Yong(yong.fan@ieee.org)
摘要	The mechanism underlying the alteration of neural activity in the human brain and the vigilance level during sleep deprivation (SD) remains a subject of ongoing investigation, particularly with regard to the sensorimotor and visual systems. Resting-state functional magnetic resonance imaging (rfMRI), a noninvasive imaging technology reflecting spontaneous activity of the human brain, is widely used in SD research. In the present study, nine repeated rfMRI sessions followed by a psychomotor vigilance task (PVT) were used to explore the alteration of neural activity and vigilance level during 36 h of SD in 23 volunteers. Mean reaction time (MRT) and lapse ratio (LR) based on PVT were measured to assess variation in vigilance level. The sensorimotor network (SMN) and visual network (VN) are the most vulnerable areas after obtaining SD measures from ReHo (regional homogeneity) and ALFF (amplitude of low-frequency fluctuation) based on rfMRI. Group-ICA was used to parcellate the visual-related regions into visual area I, visual area II, and the visual association area. Sensorimotor-related regions, including the bilateral precentral/postcentral gyms, the bilateral paracentral lobule, and the supplementary motor area (SMA), were extracted from the anatomical automatic labeling (AAL) templates. Brain neural activity and vigilance level were deteriorated at 16-30 h of SD. A 2 x 3 repeated-measures ANOVA was used to explore the effects of sleep pressure and circadian rhythm and their interaction on neural activities of sensorimotor-related and visual-related regions. Significant effects of sleep pressure and interaction on all sensorimotor-related and visual-related regions were observed. Pearson's correlation coefficients were used to explore the relationships between variation in vigilance level and alteration in brain neural activities of sensorimotor-related and visual-related regions. Significant correlations were observed between the neural activities of all sensorimotor-related regions and variation in vigilance during SD. Our results confirmed that SD alters the vigilance level and neural activity of the SMN and the VN, beginning at 24: 00 on the first day, and sleep pressure and circadian rhythm regulate the neural activity of the SMN and VN during SD. Furthermore, sleep pressure significantly regulates the effects of circadian rhythm. The enhancement of ReHo in the SMN and VN leads to a weakening of their remote connections, which may be the cause of the slowing of response time during SD.
关键词	resting-state fMRI sleep deprivation sensorimotor cortex visual cortex brain neural activity
DOI	10.16476/j.pibb.2019.0055
关键词[WOS]	DEFAULT MODE NETWORK ; RESTING STATE FMRI ; CINGULATE CORTEX ; REGIONAL HOMOGENEITY ; REACTION-TIME ; TASK ; CONNECTIVITY ; PERFORMANCE ; MELATONIN ; ACTIVATION
收录类别	SCI
语种	英语
资助项目	National Basic Research Program of China[2015CB856400] ; National Basic Research Program of China[2015CB351701] ; National Natural Science Foundation of China[81501158] ; National Natural Science Foundation of China[31730039] ; National Natural Science Foundation of China[31671133] ; National Major Scientific Instruments and Equipment Development Project[ZDYZ2015-2] ; Chinese Academy of Sciences Strategic Priority Research Program B grants[XDBS32000000] ; National Basic Research Program of China[2015CB856400] ; National Basic Research Program of China[2015CB351701] ; National Natural Science Foundation of China[81501158] ; National Natural Science Foundation of China[31730039] ; National Natural Science Foundation of China[31671133] ; National Major Scientific Instruments and Equipment Development Project[ZDYZ2015-2] ; Chinese Academy of Sciences Strategic Priority Research Program B grants[XDBS32000000]
项目资助者	National Basic Research Program of China ; National Natural Science Foundation of China ; National Major Scientific Instruments and Equipment Development Project ; Chinese Academy of Sciences Strategic Priority Research Program B grants
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000516886500005
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/38466
专题	模式识别国家重点实验室
通讯作者	Zuo Zhen-Tao; Fan Yong
作者单位	1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 4.Univ Chinese Acad Sci, Sino Danish Coll, Beijing 100049, Peoples R China 5.Chinese Acad Sci, CAS Ctr Excellence Brain & Sci & Intelligence Tec, Shanghai 200031, Peoples R China 6.Univ Penn, Perelman Sch Med, Dept Neurol, Philadelphia, PA 19104 USA 7.Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Zhang Dai,Zuo Zhen-Tao,Rao Heng-Yi,et al. Alteration of Neural Activity in The Sensorimotor and Visual Cortices and Vigilance Level During Sleep Deprivation[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2020,47(2):139-156.
APA	Zhang Dai,Zuo Zhen-Tao,Rao Heng-Yi,&Fan Yong.(2020).Alteration of Neural Activity in The Sensorimotor and Visual Cortices and Vigilance Level During Sleep Deprivation.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,47(2),139-156.
MLA	Zhang Dai,et al."Alteration of Neural Activity in The Sensorimotor and Visual Cortices and Vigilance Level During Sleep Deprivation".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 47.2(2020):139-156.