Sparse regularization-based reconstruction for bioluminescence tomography using a multilevel adaptive finite element method

	Sparse regularization-based reconstruction for bioluminescence tomography using a multilevel adaptive finite element method
	He, Xiaowei; Hou, Yanbin; Chen, Duofang; Jiang, Yuchuan; Shen, Man; Liu, Junting; Zhang, Qitan; Tian, Jie
Source Publication	International Journal of Biomedical Imaging
	2011
Volume	2011 Issue:203537 Pages:11
Abstract	Bioluminescence tomography (BLT) is a promising tool for studying physiological and pathological processes at cellular andmolecular levels. In most clinical or preclinical practices, fine discretization is needed for recovering sources with acceptable resolution when solving BLT with finite element method (FEM).Nevertheless, uniformly fine meshes would cause large dataset andoverfine meshes might aggravate the ill-posedness of BLT. Additionally, accurately quantitative information of density and power has not been simultaneously obtained so far. In this paper, we present a novel multilevel sparse reconstruction method based on adaptive FEM framework. In this method, permissible source region gradually reduces with adaptive local mesh refinement. By using sparse reconstruction with l1 regularization on multilevel adaptive meshes, simultaneous recovery of density and power as well as accurate source location can be achieved. Experimental results for heterogeneous phantom and mouse atlas model demonstrate its effectiveness and potentiality in the application of quantitative BLT
Keyword	Bioluminescence
Indexed By	EI
WOS ID	WOS:20104613398336
Citation statistics
Document Type	期刊论文
Identifier	http://ir.ia.ac.cn/handle/173211/3893
Collection	中国科学院分子影像重点实验室
Corresponding Author	Tian, Jie
Recommended Citation GB/T 7714	He, Xiaowei,Hou, Yanbin,Chen, Duofang,et al. Sparse regularization-based reconstruction for bioluminescence tomography using a multilevel adaptive finite element method[J]. International Journal of Biomedical Imaging,2011,2011(203537):11.
APA	He, Xiaowei.,Hou, Yanbin.,Chen, Duofang.,Jiang, Yuchuan.,Shen, Man.,...&Tian, Jie.(2011).Sparse regularization-based reconstruction for bioluminescence tomography using a multilevel adaptive finite element method.International Journal of Biomedical Imaging,2011(203537),11.
MLA	He, Xiaowei,et al."Sparse regularization-based reconstruction for bioluminescence tomography using a multilevel adaptive finite element method".International Journal of Biomedical Imaging 2011.203537(2011):11.

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