CASIA OpenIR  > 中国科学院分子影像重点实验室
Sparse regularization-based reconstruction for bioluminescence tomography using a multilevel adaptive finite element method
He, Xiaowei; Hou, Yanbin; Chen, Duofang; Jiang, Yuchuan; Shen, Man; Liu, Junting; Zhang, Qitan; Tian, Jie
Source PublicationInternational Journal of Biomedical Imaging
2011
Volume2011Issue:203537Pages:11
AbstractBioluminescence tomography (BLT) is a promising tool for studying physiological and pathological processes at cellular andmolecular levels. In most clinical or preclinical practices, fine discretization is needed for recovering sources with acceptable
resolution when solving BLT with finite element method (FEM).Nevertheless, uniformly fine meshes would cause large dataset andoverfine meshes might aggravate the ill-posedness of BLT. Additionally, accurately quantitative information of density and power
has not been simultaneously obtained so far. In this paper, we present a novel multilevel sparse reconstruction method based on adaptive FEM framework. In this method, permissible source region gradually reduces with adaptive local mesh refinement.
By using sparse reconstruction with l1 regularization on multilevel adaptive meshes, simultaneous recovery of density and power as well as accurate source location can be achieved. Experimental results for heterogeneous phantom and mouse atlas model
demonstrate its effectiveness and potentiality in the application of quantitative BLT
KeywordBioluminescence
Indexed ByEI
WOS IDWOS:20104613398336
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3893
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Recommended Citation
GB/T 7714
He, Xiaowei,Hou, Yanbin,Chen, Duofang,et al. Sparse regularization-based reconstruction for bioluminescence tomography using a multilevel adaptive finite element method[J]. International Journal of Biomedical Imaging,2011,2011(203537):11.
APA He, Xiaowei.,Hou, Yanbin.,Chen, Duofang.,Jiang, Yuchuan.,Shen, Man.,...&Tian, Jie.(2011).Sparse regularization-based reconstruction for bioluminescence tomography using a multilevel adaptive finite element method.International Journal of Biomedical Imaging,2011(203537),11.
MLA He, Xiaowei,et al."Sparse regularization-based reconstruction for bioluminescence tomography using a multilevel adaptive finite element method".International Journal of Biomedical Imaging 2011.203537(2011):11.
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