CASIA OpenIR  > 中国科学院分子影像重点实验室
Methylene Blue–Based Near-Infrared Fluorescence Imaging for Breast Cancer Visualization in Resected Human Tissues
Zhang, Chong1,2,3; Jiang, Daqing4; Huang, Bo5; Wang, Cong4; Zhao, Lin4; Xie, Xianxin4; Zhang, Zhaohe6; Wang, Kun1,2,3; Tian, Jie1,2,3,7; Luo, Yahong6
Source PublicationTechnology in Cancer Research & Treatment
2019
Volume18Issue:-Pages:-
Abstract

Breast-conserving surgery (BCS) is facing the challenge of objective tumor margin identification intraoperatively. Near-infrared fluorescence imaging (NIR-FI) would be an ideal approach to visualize tumor margins during surgeries. In this preliminary study, the feasibility of methylene blue (MB) based NIR-FI technique for breast cancer detection were assessed in resected human breast specimens after breast cancer surgeries. Thirty breast cancer patients scheduled for surgical treatment were enrolled, including 10 patients with preoperative chemotherapy and 20 patients without. Each of them received an injection of 1 mg/kg MB intravenously 3 hours before the surgery. Then, a home-developed MB specific NIR-FI system was employed to imaging the resected breast tissues and identify the tumor by the fluorescence contrast. Specimens were taken for pathological examinations as the reference. There were no severe adverse events attributable to MB. 16/20 patients, who did not receive preoperative chemotherapy, exhibited fluorescent contrast on their resected tissues (SBR: 1.94 ± 0.71). In contrast, tumors were identified in 3/10 specimens from patients who underwent preoperative chemotherapy (SBR: 1.63 ± 0.38). Total 35 tissues were sampled from 30 specimens. Besides 30 tumor samples, 5 more suspicious samples with fluorescence signal were confirmed to be benign hemorrhagic tissues. Therefore, a sensitivity of 0.63 and a positive predictive value of 0.79 were achieved by the MB fluorescence imaging strategy. Here we demonstrate the feasibility of using MB-FI to identify breast cancer. Preoperative chemotherapy had an impact on imaging effect, which may reduce the detection rate. After all, MB-FI has great potential to be used into BCS for tumor-positive margins detection, but further clinical trial study is needed. (http://www.chictr.org.cn/ Clinical Trial Registry ID: ChiCTR1800015400, Near-infrared fluorescence imaging applied in breast cancer identification with Methylene Blue)

Keywordnear-infrared fluorescence imaging intraoperative imaging fluorescence contrast agent breast cancer surgery methylene blue
DOI10.1177/1533033819894331
Sub direction classification医学影像处理与分析
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/39023
Collection中国科学院分子影像重点实验室
Corresponding AuthorWang, Kun; Tian, Jie; Luo, Yahong
Affiliation1.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, Chin
2.School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China
3.Beijing Key Laboratory of Molecular Imaging, Beijing, China
4.Department of Surgery, Cancer Hospital of China Medical University, Dadong District, Shenyang, Liaoning, China
5.Department of Pathology, Cancer Hospital of China Medical University, Dadong District, Shenyang, Liaoning, China
6.Department of Radiology, Cancer Hospital of China Medical University, Dadong District, Shenyang, Liaoning, China
7.Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing, China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Chong,Jiang, Daqing,Huang, Bo,等. Methylene Blue–Based Near-Infrared Fluorescence Imaging for Breast Cancer Visualization in Resected Human Tissues[J]. Technology in Cancer Research & Treatment,2019,18(-):-.
APA Zhang, Chong.,Jiang, Daqing.,Huang, Bo.,Wang, Cong.,Zhao, Lin.,...&Luo, Yahong.(2019).Methylene Blue–Based Near-Infrared Fluorescence Imaging for Breast Cancer Visualization in Resected Human Tissues.Technology in Cancer Research & Treatment,18(-),-.
MLA Zhang, Chong,et al."Methylene Blue–Based Near-Infrared Fluorescence Imaging for Breast Cancer Visualization in Resected Human Tissues".Technology in Cancer Research & Treatment 18.-(2019):-.
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