Acupuncture modulates spontaneous activities in the anticorrelated resting brain networks

	Acupuncture modulates spontaneous activities in the anticorrelated resting brain networks
	Bai, Lijun 2; Qin, Wei 2; Tian, Jie 1,2; Dong, Minghao 2; Pan, Xiaohong 5; Chen, Peng6 ; Dai, Jianping 7; Yang, Wanhai 8; Liu, Yijun 3,4
发表期刊	BRAIN RESEARCH
	2009-07-07
卷号	1279 期号:2009 页码:37-49
文章类型	Article
摘要	Neuroimaging studies of acupuncture have demonstrated extensive signal attenuations in the core regions of a "default mode" network as well as signal potentiations in the regions of a "central-executive" network. We proposed that this acupuncture-related dichotomy may represent the anticorrelation in these intrinsic brain networks showing spontaneous fluctuations during rest. According to a plentiful clinical report, acupuncture can provide pain relief beyond the time it is being administrated; therefore, imaging its sustained effect (rather than acute effect) on the brain networks may further help elucidate the mechanisms by which acupuncture achieves its therapeutic effects. As ail interface, the anterior insula (AI) has recently been shown to be a network hub, which initiates dynamic switching between these intrinsic networks. Here, we attempt to explore how acupuncture can modulate spontaneous coherences of these resting networks anchored by the AI. Using a spontaneous activity detection approach, we identified an AI-related dichotomy showing spontaneous activations in the CEN along with wide spontaneous deactivations located exclusively in the DMN. Following verum acupuncture, but not sham control, there was a prominently enhanced dichotomy in the CEN and DMN networks. More importantly, a long-lasting effect of acupuncture could further modulate intrinsic coherences of the wide interoceptive-autonomic areas, including the paralimbic regions and brainstem nuclei. These findings suggested that acupuncture may not only enhance the dichotomy of the anticorrelated resting networks, but also modulate a larger spatio-temporal extent of spontaneous activities in the salient interoceptive-autonomic network, contributing to potential actions in the endogenous pain-modulation circuits and homeostatic control mechanisms. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
关键词	Accupuncture Insula Endogenous Pain Modulation Spontaneous Brain Activity Anticorrelated Resting Brain Network
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	OLD-WORLD MONKEY ; DEFAULT-MODE ; FUNCTIONAL CONNECTIVITY ; PHYSIOLOGICAL CONDITION ; STIMULATION ; FMRI ; ACTIVATION ; INFORMATION ; CORTEX ; STATE
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000267674100005
引用统计	被引频次：98[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3909
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Chinese Acad Sci, Inst Automat, Key Lab Complex Syst & Intelligence Sci, Med Image Proc Grp, Beijing 100190, Peoples R China 2.Xidian Univ, Life Sci Res Ctr, Sch Life Sci & Technol, Xian 710071, Peoples R China 3.Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32610 USA 4.Univ Florida, Dept Neurosci, McKnight Brain Inst, Gainesville, FL 32610 USA 5.E China Normal Univ, Dept Psychol, Sch Educ Sci, Shanghai, Peoples R China 6.Capital Med Univ, Beijing Tradit Chinese Med Hosp, Beijing, Peoples R China 7.Capital Univ Med Sci, Dept Radiol, Beijing Tiantan Hosp, Beijing, Peoples R China 8.Xidian Univ, Life Sci Res Ctr, Sch Elect Engn, Xian 710071, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Bai, Lijun,Qin, Wei,Tian, Jie,et al. Acupuncture modulates spontaneous activities in the anticorrelated resting brain networks[J]. BRAIN RESEARCH,2009,1279(2009):37-49.
APA	Bai, Lijun.,Qin, Wei.,Tian, Jie.,Dong, Minghao.,Pan, Xiaohong.,...&Liu, Yijun.(2009).Acupuncture modulates spontaneous activities in the anticorrelated resting brain networks.BRAIN RESEARCH,1279(2009),37-49.
MLA	Bai, Lijun,et al."Acupuncture modulates spontaneous activities in the anticorrelated resting brain networks".BRAIN RESEARCH 1279.2009(2009):37-49.

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