Altered small-world brain functional networks and duration of heroin use in male abstinent heroin-dependent individuals

	Altered small-world brain functional networks and duration of heroin use in male abstinent heroin-dependent individuals
	Yuan, Kai 2; Qin, Wei 2; Liu, Jixin 2; Guo, Qian 2; Dong, Minghao 2; Sun, Jinbo 2; Zhang, Yi 2; Liu, Peng 2; Wang, Wei 3; Wang, Yarong 3; Li, Qiang3 ; Yang, Weichuan 3; von Deneen, Karen M.4; Gold, Mark S.4; Liu, Yijun 4; Tian, Jie 1,2
发表期刊	NEUROSCIENCE LETTERS
	2010-06-14
卷号	477 期号:1 页码:37-42
文章类型	Article
摘要	Although previous studies reported addiction-related alteration in resting-state brain connectivity, it is unclear whether these resting-state connectivity alterations were associated with chronic heroin use. In the current study, graph theory analysis (GTA) was applied to detect abnormal topological properties in heroin-dependent individuals. Several statistical parameters, such as degree (D), clustering coefficient (C) and shortest absolute path length (L), were included to test whether or not there was significant correlation between these parameters and the duration of heroin use. Our results demonstrated abnormal topological properties in several brain regions among our heroin-dependent subjects. Some of these regions are key areas of drug addiction-related circuits (control, reward, motivation/drive and memory), while others are involved in stress regulation. In addition, the duration of heroin use was positively correlated with the parameter Din the right parahippocampal gyrus, left putamen and bilateral cerebellum, but negatively correlated with the parameter L in the same regions. Our findings suggested that there is abnormal functional organization in heroin-dependent individuals and that the duration of heroin use is a critical factor leading to the altered brain connectivity. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
关键词	Heroin Resting-state Graph Theory Analysis
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	COCAINE ADDICTION ; STRESS ; CONNECTIVITY ; DRUG ; FMRI ; SENSITIVITY ; HYPOTHESIS ; DISEASE ; RELAPSE ; CORTEX
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000279045600009
引用统计	被引频次：62[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3913
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 2.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Peoples R China 3.Fourth Mil Med Univ, Xian 710038, Shaanxi, Peoples R China 4.Univ Florida, McKnight Brain Inst, Dept Psychiat & Neurosci, Gainesville, FL 32610 USA
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Yuan, Kai,Qin, Wei,Liu, Jixin,et al. Altered small-world brain functional networks and duration of heroin use in male abstinent heroin-dependent individuals[J]. NEUROSCIENCE LETTERS,2010,477(1):37-42.
APA	Yuan, Kai.,Qin, Wei.,Liu, Jixin.,Guo, Qian.,Dong, Minghao.,...&Tian, Jie.(2010).Altered small-world brain functional networks and duration of heroin use in male abstinent heroin-dependent individuals.NEUROSCIENCE LETTERS,477(1),37-42.
MLA	Yuan, Kai,et al."Altered small-world brain functional networks and duration of heroin use in male abstinent heroin-dependent individuals".NEUROSCIENCE LETTERS 477.1(2010):37-42.

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