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Altered small-world brain functional networks and duration of heroin use in male abstinent heroin-dependent individuals
Yuan, Kai2; Qin, Wei2; Liu, Jixin2; Guo, Qian2; Dong, Minghao2; Sun, Jinbo2; Zhang, Yi2; Liu, Peng2; Wang, Wei3; Wang, Yarong3; Li, Qiang3; Yang, Weichuan3; von Deneen, Karen M.4; Gold, Mark S.4; Liu, Yijun4; Tian, Jie1,2
Source PublicationNEUROSCIENCE LETTERS
2010-06-14
Volume477Issue:1Pages:37-42
SubtypeArticle
AbstractAlthough previous studies reported addiction-related alteration in resting-state brain connectivity, it is unclear whether these resting-state connectivity alterations were associated with chronic heroin use. In the current study, graph theory analysis (GTA) was applied to detect abnormal topological properties in heroin-dependent individuals. Several statistical parameters, such as degree (D), clustering coefficient (C) and shortest absolute path length (L), were included to test whether or not there was significant correlation between these parameters and the duration of heroin use. Our results demonstrated abnormal topological properties in several brain regions among our heroin-dependent subjects. Some of these regions are key areas of drug addiction-related circuits (control, reward, motivation/drive and memory), while others are involved in stress regulation. In addition, the duration of heroin use was positively correlated with the parameter Din the right parahippocampal gyrus, left putamen and bilateral cerebellum, but negatively correlated with the parameter L in the same regions. Our findings suggested that there is abnormal functional organization in heroin-dependent individuals and that the duration of heroin use is a critical factor leading to the altered brain connectivity. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
KeywordHeroin Resting-state Graph Theory Analysis
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordCOCAINE ADDICTION ; STRESS ; CONNECTIVITY ; DRUG ; FMRI ; SENSITIVITY ; HYPOTHESIS ; DISEASE ; RELAPSE ; CORTEX
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000279045600009
Citation statistics
Cited Times:40[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3913
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Peoples R China
3.Fourth Mil Med Univ, Xian 710038, Shaanxi, Peoples R China
4.Univ Florida, McKnight Brain Inst, Dept Psychiat & Neurosci, Gainesville, FL 32610 USA
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yuan, Kai,Qin, Wei,Liu, Jixin,et al. Altered small-world brain functional networks and duration of heroin use in male abstinent heroin-dependent individuals[J]. NEUROSCIENCE LETTERS,2010,477(1):37-42.
APA Yuan, Kai.,Qin, Wei.,Liu, Jixin.,Guo, Qian.,Dong, Minghao.,...&Tian, Jie.(2010).Altered small-world brain functional networks and duration of heroin use in male abstinent heroin-dependent individuals.NEUROSCIENCE LETTERS,477(1),37-42.
MLA Yuan, Kai,et al."Altered small-world brain functional networks and duration of heroin use in male abstinent heroin-dependent individuals".NEUROSCIENCE LETTERS 477.1(2010):37-42.
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