CASIA OpenIR  > 中国科学院分子影像重点实验室
Combining spatial and temporal information to explore resting-state networks changes in abstinent heroin-dependent individuals
Yuan, Kai2; Qin, Wei2; Dong, Minghao2; Liu, Jixin2; Liu, Peng2; Zhang, Yi2; Sun, Jinbo2; Wang, Wei3; Wang, Yarong3; Li, Qiang3; Yang, Weichuan3; Tian, Jie1,2
Source PublicationNEUROSCIENCE LETTERS
2010-05-07
Volume475Issue:1Pages:20-24
SubtypeArticle
AbstractMajority of previous heroin fMRI studies focused on abnormal brain function in heroin-dependent individuals. However, few fMRI studies focused on the resting-state abnormalities in heroin-dependent individuals and assessed the relationship between the resting-state functional connectivity changes and duration of heroin use. In the present study, discrete cosine transform (DCT) was employed to explore spatial distribution of low frequency BOLD oscillations in heroin-dependent individuals and healthy subjects during resting-state; meanwhile resting-state functional connectivity analysis was used to investigate the temporal signatures of overlapping brain regions obtained in DCT analysis among these two groups. Main finding of the present study is that the default mode network (DMN) and rostral anterior cingulate cortex (rACC) network of heroin-dependent individuals were changed compared with healthy subjects. More importantly, these changes negatively correlated with duration of heroin use. These resting-state functional abnormalites in heroin-dependent individuals provided evidence for abnormal functional organization in heroin-dependent individuals, such as functional impairments in decision-making and inhibitory control. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
KeywordResting-state Discrete Cosine Transform (Dct) Heroin Functional Connectivity Region Of Interest (Roi)
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordDEFAULT-MODE NETWORK ; DRUG-RELATED CUES ; FUNCTIONAL CONNECTIVITY ; ALZHEIMERS-DISEASE ; OPIATE DEPENDENCE ; HUMAN BRAIN ; FMRI ; COCAINE ; STRESS ; SENSITIVITY
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000277966100005
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3920
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
2.Xidian Univ, Life Sci Res Ctr, Sch Life Sci & Technol, Xian 710071, Peoples R China
3.Fourth Mil Med Univ, Xian 710038, Shaanxi, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yuan, Kai,Qin, Wei,Dong, Minghao,et al. Combining spatial and temporal information to explore resting-state networks changes in abstinent heroin-dependent individuals[J]. NEUROSCIENCE LETTERS,2010,475(1):20-24.
APA Yuan, Kai.,Qin, Wei.,Dong, Minghao.,Liu, Jixin.,Liu, Peng.,...&Tian, Jie.(2010).Combining spatial and temporal information to explore resting-state networks changes in abstinent heroin-dependent individuals.NEUROSCIENCE LETTERS,475(1),20-24.
MLA Yuan, Kai,et al."Combining spatial and temporal information to explore resting-state networks changes in abstinent heroin-dependent individuals".NEUROSCIENCE LETTERS 475.1(2010):20-24.
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