CASIA OpenIR  > 中国科学院分子影像重点实验室
Distinct resting-state brain activities in heroin-dependent individuals
Zhang, Yi1,2; Tian, Jie1,3; Yuan, Kai1; Liu, Peng1; Zhuo, Lu1; Qin, Wei1; Zhao, Liyan4; Liu, Jixin1; von Deneen, Karen M.1,2; Klahr, Nelson J.2; Gold, Mark S.2; Liu, Yijun2
Source PublicationBRAIN RESEARCH
2011-07-21
Volume1402Issue:2011Pages:46-53
SubtypeArticle
AbstractPrevious functional imaging studies on heroin addicts have focused on abnormal brain functions based on specific tasks, while few fMRI studies concentrated on the resting-state abnormalities of heroin-dependent individuals. In the current study, we applied the pattern classification technique, which employs the feature extraction method of non-negative matrix factorization (NMF) and a support vector machine (SVM) classifier. Its main purpose was to characterize the discrepancy in activation patterns between heroin-dependent individuals and healthy subjects during the resting state. The results displayed a high accuracy in the activation pattern differences of the two groups, which included the orbitofrontal cortex pm, cingulate gyrus, frontal and para-limbic regions such as the anterior cingulate cortex (ACC), hippocampal/parahippocampal region, amygdala, caudate, putamen, as well as the posterior insula and thalamus. These findings indicate that significant biomarkers exist among the network of circuits that are involved in drug abuse. The implications from our study may help explain the behavioral and neuropsychological deficits in heroin-dependent individuals and shed light on the mechanisms underlying heroin addiction. (C) 2011 Elsevier B.V. All rights reserved.
KeywordHeroin-dependent Individuals Pattern Classification Multi-voxel Pattern Analysis (Mvpa) Non-negative Matrix Factorization (Nmf) Support Vector Machine (Svm)
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordSTRIATAL DOPAMINE RELEASE ; SUPPORT VECTOR MACHINES ; HUMAN VISUAL-CORTEX ; COCAINE ADDICTION ; ORBITOFRONTAL CORTEX ; NEUROIMAGING EVIDENCE ; SUBJECTIVE RESPONSES ; DRUG-ADDICTION ; FMRI DATA ; STRESS
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000293312300006
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3925
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
2.Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32610 USA
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Yi,Tian, Jie,Yuan, Kai,et al. Distinct resting-state brain activities in heroin-dependent individuals[J]. BRAIN RESEARCH,2011,1402(2011):46-53.
APA Zhang, Yi.,Tian, Jie.,Yuan, Kai.,Liu, Peng.,Zhuo, Lu.,...&Liu, Yijun.(2011).Distinct resting-state brain activities in heroin-dependent individuals.BRAIN RESEARCH,1402(2011),46-53.
MLA Zhang, Yi,et al."Distinct resting-state brain activities in heroin-dependent individuals".BRAIN RESEARCH 1402.2011(2011):46-53.
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