Dysfunctional connectivity patterns in chronic heroin users: An fMRI study

	Dysfunctional connectivity patterns in chronic heroin users: An fMRI study
	Liu, Jixin 1; Liang, Jimin 1; Qin, Wei 1; Tian, Jie 1,2; Yuan, Kai 1; Bai, Lijun 1; Zhang, Yi 1; Wang, Wei 3; Wang, Yarong 3; Li, Qiang3 ; Zhao, Liyan 4; Lu, Lin 4; von Deneen, Karen M.5,6; Liu, Yijun 5,6; Gold, Mark S.5,6
发表期刊	NEUROSCIENCE LETTERS
	2009-08-21
卷号	460 期号:1 页码:72-77
文章类型	Article
摘要	Recent functional neuroimaging studies have examined cognitive inhibitory control, decision-making and stress regulation in heroin addiction using a cue-reactivity paradigm. Few studies have considered impairments in heroin users from an integrated perspective for evaluation of their brain functions. We hypothesized that the brain regions that are dysregulated in the chronic heroin users during cue-reactivity studies may also show dysfunctional connectivity in memory, inhibition and motivation-related dysfunctions during a resting state free of cues. The present study used resting functional magnetic resonance imaging (fMRI) to compare the interaction of brain regions between 12 chronic heroin users and 12 controls by employing a novel graph theory analysis (GTA) method. As a data-driven approach, GTA has the advantage of evaluating the strength as well as the temporal and spatial patterns of interactions among the brain regions. Abnormal topological properties were explored in the brain of chronic heroin users, such as the dysfunctional connectivity in the prefrontal cortex, ACC, SMA, ventral striatum, insula, amygdala and hippocampus. Our results suggest that GTA is a useful tool in defining dysregulated neural networks even during rest. This dysfunctional brain connectivity may contribute to decrease self-control, impaired inhibitory function as well deficits in stress regulation in chronic heroin users. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
关键词	Fmri Chronic Heroin User Graph Theory Analysis Resting State
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	NEUROIMAGING EVIDENCE ; DRUG-ADDICTION ; HUMAN BRAIN ; STRESS ; INTEGRATION ; NETWORKS ; RELAPSE ; CORTEX ; NEUROBIOLOGY ; ASSOCIATION
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000267633400015
引用统计	被引频次：109[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3928
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Xidian Univ, Sch Elect Engn, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 3.Fourth Mil Med Univ, Xian 710038, Shaanxi, Peoples R China 4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China 5.Univ Florida, McKnight Brain Inst, Dept Psychiat, Gainesville, FL 32610 USA 6.Univ Florida, McKnight Brain Inst, Dept Neurosci, Gainesville, FL 32610 USA
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Liu, Jixin,Liang, Jimin,Qin, Wei,et al. Dysfunctional connectivity patterns in chronic heroin users: An fMRI study[J]. NEUROSCIENCE LETTERS,2009,460(1):72-77.
APA	Liu, Jixin.,Liang, Jimin.,Qin, Wei.,Tian, Jie.,Yuan, Kai.,...&Gold, Mark S..(2009).Dysfunctional connectivity patterns in chronic heroin users: An fMRI study.NEUROSCIENCE LETTERS,460(1),72-77.
MLA	Liu, Jixin,et al."Dysfunctional connectivity patterns in chronic heroin users: An fMRI study".NEUROSCIENCE LETTERS 460.1(2009):72-77.

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