CASIA OpenIR  > 中国科学院分子影像重点实验室
Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models
Liu, Kai1; Lu, Yujie2; Tian, Jie1,3; Qin, Chenghu1; Yang, Xin1; Zhu, Shouping3; Yang, Xiang1,3; Gao, Quansheng4; Han, Dong1
Source PublicationOPTICS EXPRESS
2010-09-27
Volume18Issue:20Pages:20988-21002
SubtypeArticle
AbstractIn vivo bioluminescence imaging (BLI) has played a more and more important role in biomedical research of small animals. Bioluminescence tomography (BLT) further translates the BLI optical information into three-dimensional bioluminescent source distribution, which could greatly facilitate applications in related studies. Although the diffusion approximation (DA) is one of the most widely-used forward models, higher-order approximations are still needed for in vivo small animal imaging. In this work, as a higher-order approximation theory, the performance of the simplified spherical harmonics approximation (SPN) in BLT is evaluated thoroughly on heterogeneous mouse models. In the numerical validations, the SPN based results demonstrate better imaging quality compared with diffusion approximation heterogeneously under various source locations over wide optical domain. In what follows, heterogeneous experimental BLT reconstructions using in vivo mouse further evaluate the capability of the higher-order method for practical biomedical applications. (C) 2010 Optical Society of America
KeywordTomography Inverse Problem Light Propagation Spectroscopy Fluorescence Luminescence
WOS HeadingsScience & Technology ; Physical Sciences
WOS KeywordDIFFUSE OPTICAL TOMOGRAPHY ; IMAGE-RECONSTRUCTION ; BIOLOGICAL TISSUE ; RADIATIVE-TRANSFER ; PHOTON MIGRATION ; LIGHT TRANSPORT ; SIMULATION ; EQUATIONS ; FEASIBILITY ; SYSTEM
Indexed BySCI
Language英语
WOS Research AreaOptics
WOS SubjectOptics
WOS IDWOS:000283679200045
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3933
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing 100190, Peoples R China
2.Univ Calif Los Angeles, David Geffen Sch Med, Crump Inst Mol Imaging, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
3.Xidian Univ, Sch Life Sci & Technol, Life Sci Ctr, Xian 710071, Shaanxi, Peoples R China
4.Acad Mil Med Sci, Lab Anim Ctr, Beijing 100850, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Liu, Kai,Lu, Yujie,Tian, Jie,et al. Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models[J]. OPTICS EXPRESS,2010,18(20):20988-21002.
APA Liu, Kai.,Lu, Yujie.,Tian, Jie.,Qin, Chenghu.,Yang, Xin.,...&Han, Dong.(2010).Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models.OPTICS EXPRESS,18(20),20988-21002.
MLA Liu, Kai,et al."Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models".OPTICS EXPRESS 18.20(2010):20988-21002.
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