Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation

	Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation
	Hu, Zhenhua1 ; Liang, Jimin 1; Yang, Weidong 2; Fan, Weiwei 3; Li, Congye 3; Ma, Xiaowei 2; Chen, Xueli 1; Ma, Xiaopeng 1; Li, Xiangsi 1; Qu, Xiaochao 1; Wang, Jing 2; Cao, Feng 3; Tian, Jie 1,4
发表期刊	OPTICS EXPRESS
	2010-11-22
卷号	18 期号:24 页码:24441-24450
文章类型	Article
摘要	Optical molecular imaging resulting from Cerenkov radiation has become a motivating topic recently and will potentially open new avenues for the study of small animal imaging. Cerenkov-based optical imaging taken from living animals in vivo has been studied with two-dimensional (2D) planar geometry and three-dimensional (3D) homogeneous mouse model. In this study, we performed 3D Cerenkov-based luminescence tomography (CLT) using a heterogeneous mouse model with an implanted Na(131)I radioactive source, which provided the accurate location for the reconstructed source. Furthermore, single photon emission computed tomography (SPECT) was utilized to verify the results of 3D CLT. We reconstructed the localization and intensity of an embedded radioactive source with various concentrations, and established a quantitative relationship between the radiotracer activity and the reconstructed intensity. The results showed the ability of in vivo CLT to recover the radioactive probe distribution in the heterogeneous mouse model and the potential of a SPECT imaging validation strategy to verify the results of optical molecular tomography. (C) 2010 Optical Society of America
关键词	Medical And Biological Imaging Tomography Luminescence Functional Monitoring And Imaging Light Propagation In Tissues
WOS标题词	Science & Technology ; Physical Sciences
关键词[WOS]	POSITRON-EMITTING RADIOTRACERS ; FINITE-ELEMENT ALGORITHM ; BIOLUMINESCENCE TOMOGRAPHY ; FLUORESCENCE TOMOGRAPHY ; RECONSTRUCTION ; LIGHT ; RADIATION ; SYSTEM
收录类别	SCI
语种	英语
WOS研究方向	Optics
WOS类目	Optics
WOS记录号	WOS:000285586800058
引用统计	被引频次：109[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3934
专题	中国科学院分子影像重点实验室
通讯作者	Wang, Jing
作者单位	1.Xidian Univ, Life Sci Res Ctr, Sch Life Sci & Technol, Xian 710071, Peoples R China 2.Fourth Mil Med Univ, Dept Nucl Med, Xijing Hosp, Xian 710032, Peoples R China 3.Fourth Mil Med Univ, Dept Cardiol, Xijing Hosp, Xian 710032, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Hu, Zhenhua,Liang, Jimin,Yang, Weidong,et al. Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation[J]. OPTICS EXPRESS,2010,18(24):24441-24450.
APA	Hu, Zhenhua.,Liang, Jimin.,Yang, Weidong.,Fan, Weiwei.,Li, Congye.,...&Tian, Jie.(2010).Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation.OPTICS EXPRESS,18(24),24441-24450.
MLA	Hu, Zhenhua,et al."Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation".OPTICS EXPRESS 18.24(2010):24441-24450.

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