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Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation
Hu, Zhenhua1; Liang, Jimin1; Yang, Weidong2; Fan, Weiwei3; Li, Congye3; Ma, Xiaowei2; Chen, Xueli1; Ma, Xiaopeng1; Li, Xiangsi1; Qu, Xiaochao1; Wang, Jing2; Cao, Feng3; Tian, Jie1,4
Source PublicationOPTICS EXPRESS
2010-11-22
Volume18Issue:24Pages:24441-24450
SubtypeArticle
AbstractOptical molecular imaging resulting from Cerenkov radiation has become a motivating topic recently and will potentially open new avenues for the study of small animal imaging. Cerenkov-based optical imaging taken from living animals in vivo has been studied with two-dimensional (2D) planar geometry and three-dimensional (3D) homogeneous mouse model. In this study, we performed 3D Cerenkov-based luminescence tomography (CLT) using a heterogeneous mouse model with an implanted Na(131)I radioactive source, which provided the accurate location for the reconstructed source. Furthermore, single photon emission computed tomography (SPECT) was utilized to verify the results of 3D CLT. We reconstructed the localization and intensity of an embedded radioactive source with various concentrations, and established a quantitative relationship between the radiotracer activity and the reconstructed intensity. The results showed the ability of in vivo CLT to recover the radioactive probe distribution in the heterogeneous mouse model and the potential of a SPECT imaging validation strategy to verify the results of optical molecular tomography. (C) 2010 Optical Society of America
KeywordMedical And Biological Imaging Tomography Luminescence Functional Monitoring And Imaging Light Propagation In Tissues
WOS HeadingsScience & Technology ; Physical Sciences
WOS KeywordPOSITRON-EMITTING RADIOTRACERS ; FINITE-ELEMENT ALGORITHM ; BIOLUMINESCENCE TOMOGRAPHY ; FLUORESCENCE TOMOGRAPHY ; RECONSTRUCTION ; LIGHT ; RADIATION ; SYSTEM
Indexed BySCI
Language英语
WOS Research AreaOptics
WOS SubjectOptics
WOS IDWOS:000285586800058
Citation statistics
Cited Times:79[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3934
Collection中国科学院分子影像重点实验室
Corresponding AuthorWang, Jing
Affiliation1.Xidian Univ, Life Sci Res Ctr, Sch Life Sci & Technol, Xian 710071, Peoples R China
2.Fourth Mil Med Univ, Dept Nucl Med, Xijing Hosp, Xian 710032, Peoples R China
3.Fourth Mil Med Univ, Dept Cardiol, Xijing Hosp, Xian 710032, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Hu, Zhenhua,Liang, Jimin,Yang, Weidong,et al. Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation[J]. OPTICS EXPRESS,2010,18(24):24441-24450.
APA Hu, Zhenhua.,Liang, Jimin.,Yang, Weidong.,Fan, Weiwei.,Li, Congye.,...&Tian, Jie.(2010).Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation.OPTICS EXPRESS,18(24),24441-24450.
MLA Hu, Zhenhua,et al."Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation".OPTICS EXPRESS 18.24(2010):24441-24450.
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