Simulation and practice of particle inertial focusing in 3D-printed serpentine microfluidic chips via commercial 3D-printers

doi:10.1039/d0sm00084a

	Simulation and practice of particle inertial focusing in 3D-printed serpentine microfluidic chips via commercial 3D-printers
	Yin, Pengju 1; Zhao, Lei 1; Chen, Zezhou 1; Jiao, Zhiqiang 1; Shi, Hongyan 1; Hu, Bo 1; Yuan, Shifang 2; Tian, Jie 1,3
发表期刊	SOFT MATTER
ISSN	1744-683X
	2020-03-28
卷号	16 期号:12 页码:3096-3105
通讯作者	Hu, Bo(bohu@xidian.edu.cn) ; Yuan, Shifang(shifangy@fmmu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
摘要	Inertial focusing of particles in serpentine microfluidic chips has been studied over the past decade. Here, a study to investigate the particle inertial focusing in 3D-printed serpentine microfluidic chips was conducted by simulation and practice. A test model was designed and printed using four commercial 3D-printers. Commercial inkjet 3D-printers have shown the best printing channel resolution of up to 0.1 mm. The force analysis of particle inertial focusing in 3D-printed microfluidic chips with large cross-sectional channels was discussed. Important parameters such as the channel curvature and flow velocity were studied by simulation. The optimal channel curvature and flow velocity are 5.9 mm and 480 mu L min(-1) (Re: 29.8 and De: 4.49) in the 3D-printed microfluidic chips with 0.2 mm x 0.4 mm cross-sectional channels. Under these optimal conditions, particles were well focused in the middle of the channel. Furthermore, two kinds of cancer cells were focused in these 3D-printed serpentine microfluidic chips under the optimal conditions. We envision that this improved study would provide helpful insights into simulating particle inertial focusing in 3D-printed microfluidic chips and promoting 3D-printed microfluidic chips to commercial production.
DOI	10.1039/d0sm00084a
关键词[WOS]	POISEUILLE FLOW ; CANCER-CELLS ; SEPARATION ; DEVICES ; FUNDAMENTALS ; FABRICATION
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2016YFC0102000] ; National Key Research and Development Program of China[2017YFA0205202] ; National Natural Science Foundation of China[81772011] ; National Natural Science Foundation of China[31800714] ; 100 Talents Project of Shaanxi Province, China[SXBR9181] ; Natural Science Basic Research Plan in Shaanxi Province of China[2018JQ3027] ; Fundamental Research Funds for the Central Universities[JC1907] ; Doctoral Students' Short-Term Study Abroad Scholarship Fund of Xidian University
项目资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China ; 100 Talents Project of Shaanxi Province, China ; Natural Science Basic Research Plan in Shaanxi Province of China ; Fundamental Research Funds for the Central Universities ; Doctoral Students' Short-Term Study Abroad Scholarship Fund of Xidian University
WOS研究方向	Chemistry ; Materials Science ; Physics ; Polymer Science
WOS类目	Chemistry, Physical ; Materials Science, Multidisciplinary ; Physics, Multidisciplinary ; Polymer Science
WOS记录号	WOS:000526925800017
出版者	ROYAL SOC CHEMISTRY
七大方向——子方向分类	其他
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/39356
专题	中国科学院分子影像重点实验室
通讯作者	Hu, Bo; Yuan, Shifang; Tian, Jie
作者单位	1.Xidian Univ, Lib, Sch Life Sci & Technol, Xian 710126, Shaanxi, Peoples R China 2.Fourth Mil Med Univ, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Yin, Pengju,Zhao, Lei,Chen, Zezhou,et al. Simulation and practice of particle inertial focusing in 3D-printed serpentine microfluidic chips via commercial 3D-printers[J]. SOFT MATTER,2020,16(12):3096-3105.
APA	Yin, Pengju.,Zhao, Lei.,Chen, Zezhou.,Jiao, Zhiqiang.,Shi, Hongyan.,...&Tian, Jie.(2020).Simulation and practice of particle inertial focusing in 3D-printed serpentine microfluidic chips via commercial 3D-printers.SOFT MATTER,16(12),3096-3105.
MLA	Yin, Pengju,et al."Simulation and practice of particle inertial focusing in 3D-printed serpentine microfluidic chips via commercial 3D-printers".SOFT MATTER 16.12(2020):3096-3105.