Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy

doi:10.3389/fpsyt.2020.00236

	Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy
	Tao, Qi 1,2,3,4; Yang, Yongfeng 5,6,7,8; Yu, Hongyan 5; Fan, Lingzhong9,10,11 ; Luan, Shuxin 12,13; Zhang, Lei 12,13; Zhao, Hua 12; Lv, Luxian 5,6,7; Jiang, Tianzi8,9,10,11 ; Song, Xueqin 1,2,3
发表期刊	FRONTIERS IN PSYCHIATRY
ISSN	1664-0640
	2020-04-03
卷号	11 页码:8
通讯作者	Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn) ; Song, Xueqin(fccsongxq@zzu.edu.cn)
摘要	Objectives Abnormal activity of the subgenual anterior cingulate cortex (sACC) is implicated in depression, suggesting the sACC as a potentially effective target for therapeutic modulation in cases resistant to conventional treatments (treatment-resistant depression, TRD). We hypothesized that areas in the prefrontal cortex (PFC) with direct fiber connections to the sACC may be particularly effective sites for treatment using transcranial magnetic stimulation (TMS). The aim of this study was to identify PFC sites most strongly connected to the sACC. Methods Two neuroimaging data sets were used to construct anatomic and functional connectivity maps using sACC as the seed region. Data set 1 included magnetic resonance (MR) images from 20 healthy controls and Data set 2 included MR images from 15 TRD patients and 15 additional healthy controls. PFC voxels with maximum values in the mean anatomic connection probability maps were identified as optimal sites for TMS. Results Both right and left PFC contained sites strongly connected to the sACC, but the coordinates (in Montreal Neurological Institute space) of peak anatomic connectivity differed slightly between hemispheres. The left PFC site connected directly to the sACC both anatomically and functionally, while the right PFC site was functionally connected to the posterior cingulate cortex (PCC). Conclusions Both left and right PFC are functionally connected to regions implicated in depression, the sACC and PCC, respectively. These bilateral PFC sites may be effective TMS targets to treat TRD.
关键词	treatment-resistant depression (TRD) transcranial magnetic stimulation (TMS) anatomical connectivity subgenual anterior cingulated cortex (sACC) prefrontal cortex (PFC)
DOI	10.3389/fpsyt.2020.00236
关键词[WOS]	DORSOLATERAL PREFRONTAL CORTEX ; DEEP BRAIN-STIMULATION ; TREATMENT-RESISTANT DEPRESSION ; SUBCALLOSAL CINGULATE GYRUS ; CEREBRAL-BLOOD-FLOW ; MAJOR DEPRESSION ; FUNCTIONAL CONNECTIVITY ; EFFICACY ; MOOD ; RTMS
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81671330] ; National Natural Science Foundation of China[81571318] ; Medical Science and Technology Research Project of Henan Province[2018020373] ; Health and Family Planning Commission of Henan Province[201501015] ; Department of Science and Technology of Henan Province[162102410061] ; Department of Science and Technology of Henan Province[2017JQ023] ; School and Hospital Co-incubation Funds[2017-BSTDJJ-04] ; Research Council of Norway[223273]
项目资助者	National Natural Science Foundation of China ; Medical Science and Technology Research Project of Henan Province ; Health and Family Planning Commission of Henan Province ; Department of Science and Technology of Henan Province ; School and Hospital Co-incubation Funds ; Research Council of Norway
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000528705700001
出版者	FRONTIERS MEDIA SA
七大方向——子方向分类	脑网络分析
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/39372
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Jiang, Tianzi; Song, Xueqin
作者单位	1.Zhengzhou Univ, Dept Psychiat, Affiliated Hosp 1, Zhengzhou, Peoples R China 2.Zhengzhou Univ, Biol Psychiat Int Joint Lab Henan, Zhengzhou, Peoples R China 3.Zhengzhou Univ, Henan Psychiat Transformat Res Key Lab, Zhengzhou, Peoples R China 4.Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China 5.Xinxiang Med Univ, Henan Mental Hosp, Dept Psychiat, Affiliated Hosp 2, Xinxiang, Henan, Peoples R China 6.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Henan, Peoples R China 7.Int Joint Res Lab Psychiat & Neurosci Henan, Xinxiang, Henan, Peoples R China 8.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Peoples R China 9.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 10.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 11.Univ Chinese Acad Sci, Beijing, Peoples R China 12.Jilin Univ, Coll Basic Med Sci, Dept Physiol, Jilin, Jilin, Peoples R China 13.Jilin Univ, Dept Psychiat, Bethune Hosp 1, Changchun, Peoples R China
通讯作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Tao, Qi,Yang, Yongfeng,Yu, Hongyan,et al. Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy[J]. FRONTIERS IN PSYCHIATRY,2020,11:8.
APA	Tao, Qi.,Yang, Yongfeng.,Yu, Hongyan.,Fan, Lingzhong.,Luan, Shuxin.,...&Song, Xueqin.(2020).Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy.FRONTIERS IN PSYCHIATRY,11,8.
MLA	Tao, Qi,et al."Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy".FRONTIERS IN PSYCHIATRY 11(2020):8.