Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals

	Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals
	Yuan, Kai 2; Qin, Wei 2; Dong, Minghao 2; Liu, Jixin 2; Sun, Jinbo 2; Liu, Peng 2; Zhang, Yi 2; Wang, Wei 3; Wang, Yarong 3; Li, Qiang3 ; Zhao, Liyan 4; von Deneen, Karen M.5,6; Liu, Yijun 5,6; Gold, Mark S.5,6; Tian, Jie 1,2
发表期刊	NEUROSCIENCE LETTERS
	2010-09-27
卷号	482 期号:2 页码:101-105
文章类型	Article
摘要	Previous neuroimaging studies have demonstrated both structural and functional damages in heroin-dependent individuals. However, few studies investigated gray matter deficits and abnormal resting-state networks together in heroin-dependent individuals. In the present study, voxel-based morphometry (VBM) was used to identify brain regions with gray matter density reduction. Resting-state fMRI connectivity analysis was employed to assess potential functional abnormalities during resting-state. All clinical significances were investigated by examining their association with duration of heroin use. Compared with healthy subjects, heroin-dependent individuals showed significant reduction in gray matter density in the right dorsolateral prefrontal cortex (DLPFC) and a decrease in resting-state functional connectivity between the right DLPFC and left inferior parietal lobe (IPL). The gray matter density of the right DLPFC and its resting-state functional connectivity with the left IPL both showed significantly negative correlation with duration of heroin use, which were likely to be related to the functional impairments in decision-making and cognitive control exhibited by heroin-dependent individuals. Our findings demonstrated that long heroin dependence impairs the right DLPFC in heroin-dependent individuals, including structural deficits and resting-state functional impairments. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
关键词	Heroin Voxel-based Morphometry Resting-state
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	VOXEL-BASED MORPHOMETRY ; FUNCTIONAL CONNECTIVITY ; PREFRONTAL CORTEX ; OPIATE DEPENDENCE ; DEFAULT MODE ; FMRI ; BRAIN ; CUES ; NETWORKS ; COCAINE
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000281473000005
引用统计	被引频次：77[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3946
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 2.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Peoples R China 3.Fourth Mil Med Univ, Xian 710038, Shaanxi, Peoples R China 4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China 5.Univ Florida, McKnight Brain Inst, Dept Psychiat, Gainesville, FL 32610 USA 6.Univ Florida, McKnight Brain Inst, Dept Neurosci, Gainesville, FL 32610 USA
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Yuan, Kai,Qin, Wei,Dong, Minghao,et al. Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals[J]. NEUROSCIENCE LETTERS,2010,482(2):101-105.
APA	Yuan, Kai.,Qin, Wei.,Dong, Minghao.,Liu, Jixin.,Sun, Jinbo.,...&Tian, Jie.(2010).Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals.NEUROSCIENCE LETTERS,482(2),101-105.
MLA	Yuan, Kai,et al."Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals".NEUROSCIENCE LETTERS 482.2(2010):101-105.

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