In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models

	In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models
	Liu, Junting 1; Wang, Yabin 2; Qu, Xiaochao 1; Li, Xiangsi 1; Ma, Xiaopeng 1; Han, Runqiang 1; Hu, Zhenhua1 ; Chen, Xueli 1; Sun, Dongdong 2; Zhang, Rongqing 2; Chen, Duofang 1; Chen, Dan 1; Chen, Xiaoyuan 4; Liang, Jimin 1; Cao, Feng 2; Tian, Jie 1,3; J. Liang, F. Cao, J. Tian
发表期刊	OPTICS EXPRESS
	2010-06-07
卷号	18 期号:12 页码:13102-13113
文章类型	Article
摘要	Bioluminescence tomography (BLT) is a new optical molecular imaging modality, which can monitor both physiological and pathological processes by using bioluminescent light-emitting probes in small living animal. Especially, this technology possesses great potential in drug development, early detection, and therapy monitoring in preclinical settings. In the present study, we developed a dual modality BLT prototype system with Micro-computed tomography (MicroCT) registration approach, and improved the quantitative reconstruction algorithm based on adaptive hp finite element method (hp-FEM). Detailed comparisons of source reconstruction between the heterogeneous and homogeneous mouse models were performed. The models include mice with implanted luminescence source and tumor-bearing mice with firefly luciferase report gene. Our data suggest that the reconstruction based on heterogeneous mouse model is more accurate in localization and quantification than the homogeneous mouse model with appropriate optical parameters and that BLT allows super-early tumor detection in vivo based on tomographic reconstruction of heterogeneous mouse model signal. (C) 2010 Optical Society of America
关键词	-
WOS标题词	Science & Technology ; Physical Sciences
关键词[WOS]	SOURCE RECONSTRUCTION ; IMAGE-RECONSTRUCTION ; LIGHT ; PROPAGATION ; ALGORITHM ; TISSUE ; CELL
收录类别	SCI
语种	英语
WOS研究方向	Optics
WOS类目	Optics
WOS记录号	WOS:000278527700115
引用统计	被引频次：58[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3947
专题	中国科学院分子影像重点实验室
通讯作者	J. Liang, F. Cao, J. Tian
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Peoples R China 2.Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 4.NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA
推荐引用方式 GB/T 7714	Liu, Junting,Wang, Yabin,Qu, Xiaochao,et al. In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models[J]. OPTICS EXPRESS,2010,18(12):13102-13113.
APA	Liu, Junting.,Wang, Yabin.,Qu, Xiaochao.,Li, Xiangsi.,Ma, Xiaopeng.,...&J. Liang, F. Cao, J. Tian.(2010).In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models.OPTICS EXPRESS,18(12),13102-13113.
MLA	Liu, Junting,et al."In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models".OPTICS EXPRESS 18.12(2010):13102-13113.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
In vivo quantitative（336KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载