CASIA OpenIR  > 中国科学院分子影像重点实验室
In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models
Liu, Junting1; Wang, Yabin2; Qu, Xiaochao1; Li, Xiangsi1; Ma, Xiaopeng1; Han, Runqiang1; Hu, Zhenhua1; Chen, Xueli1; Sun, Dongdong2; Zhang, Rongqing2; Chen, Duofang1; Chen, Dan1; Chen, Xiaoyuan4; Liang, Jimin1; Cao, Feng2; Tian, Jie1,3; J. Liang, F. Cao, J. Tian
Source PublicationOPTICS EXPRESS
2010-06-07
Volume18Issue:12Pages:13102-13113
SubtypeArticle
AbstractBioluminescence tomography (BLT) is a new optical molecular imaging modality, which can monitor both physiological and pathological processes by using bioluminescent light-emitting probes in small living animal. Especially, this technology possesses great potential in drug development, early detection, and therapy monitoring in preclinical settings. In the present study, we developed a dual modality BLT prototype system with Micro-computed tomography (MicroCT) registration approach, and improved the quantitative reconstruction algorithm based on adaptive hp finite element method (hp-FEM). Detailed comparisons of source reconstruction between the heterogeneous and homogeneous mouse models were performed. The models include mice with implanted luminescence source and tumor-bearing mice with firefly luciferase report gene. Our data suggest that the reconstruction based on heterogeneous mouse model is more accurate in localization and quantification than the homogeneous mouse model with appropriate optical parameters and that BLT allows super-early tumor detection in vivo based on tomographic reconstruction of heterogeneous mouse model signal. (C) 2010 Optical Society of America
Keyword-
WOS HeadingsScience & Technology ; Physical Sciences
WOS KeywordSOURCE RECONSTRUCTION ; IMAGE-RECONSTRUCTION ; LIGHT ; PROPAGATION ; ALGORITHM ; TISSUE ; CELL
Indexed BySCI
Language英语
WOS Research AreaOptics
WOS SubjectOptics
WOS IDWOS:000278527700115
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3947
Collection中国科学院分子影像重点实验室
Corresponding AuthorJ. Liang, F. Cao, J. Tian
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Peoples R China
2.Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
4.NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA
Recommended Citation
GB/T 7714
Liu, Junting,Wang, Yabin,Qu, Xiaochao,et al. In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models[J]. OPTICS EXPRESS,2010,18(12):13102-13113.
APA Liu, Junting.,Wang, Yabin.,Qu, Xiaochao.,Li, Xiangsi.,Ma, Xiaopeng.,...&J. Liang, F. Cao, J. Tian.(2010).In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models.OPTICS EXPRESS,18(12),13102-13113.
MLA Liu, Junting,et al."In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models".OPTICS EXPRESS 18.12(2010):13102-13113.
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