Grading of Glioma: combined diagnostic value of amide proton transfer weighted, arterial spin labeling and diffusion weighted magnetic resonance imaging

doi:10.1186/s12880-020-00450-x

	Grading of Glioma: combined diagnostic value of amide proton transfer weighted, arterial spin labeling and diffusion weighted magnetic resonance imaging
	Kang, Xiao-wei 1,2; Xi, Yi-bin 1,2; Liu, Ting-ting 2,3; Wang, Ning 2,4; Zhu, Yuan-qiang 2; Wang, Xing-rui 2,5; Guo, Fan 2,6
发表期刊	BMC MEDICAL IMAGING
ISSN	1471-2342
	2020-05-14
卷号	20 期号:1 页码:8
通讯作者	Guo, Fan(guofan0602@hotmail.com)
摘要	Background To investigate the ability of amide proton transfer (APT) weighted magnetic resonance imaging (MRI), arterial spin labeling (ASL), diffusion weighted imaging (DWI) and the combination for differentiating high-grade gliomas (HGGs) from low-grade gliomas (LGGs). Methods Twenty-seven patients including nine LGGs and eighteen HGGs underwent conventional, APT, ASL and DWI MRI with a 3.0-T MR scanner. Histogram analyses was performed and quantitative parameters including mean apparent diffusion coefficient (ADC mean), 20th-percentile ADC (ADC 20th), mean APT (APT mean), 90th-percentile APT (APT 90th), relative mean cerebral blood flow (rCBF mean) and relative 90th-percentile CBF (rCBF 90th) were compared between HGGs and LGGs. The diagnostic performance was evaluated with receiver operating characteristic (ROC) analysis of each parameter and their combination. Correlations were analyzed among the MRI parameters and Ki-67. Results The APT values were significantly higher in the HGGs compared to the LGGs (p < 0.005), whereas ADC values were significantly lower in HGGs than LGGs (P < 0.0001). The ADC 20th and APT mean had higher discrimination abilities compared with other single parameters, with the area under the ROC curve (AUC) of 0.877 and 0.840. Adding ADC parameter, the discrimination ability of APT and rCBF significantly improved. The ADC was negatively correlated with the APT and rCBF value, respectively, while APT value was positively correlated with rCBF value. Significant correlations between ADC values and Ki-67 were also observed. Conclusions APT and DWI are valuable in differentiating HGGs from LGGs. The combination of APT, DWI and ASL imaging could improve the ability for discriminating HGGs from LGGs.
关键词	Glioma Magnetic resonance imaging Arterial spin labeling Amide proton transfer Apparent diffusion coefficient
DOI	10.1186/s12880-020-00450-x
关键词[WOS]	TRUE PROGRESSION ; BRAIN-TUMORS ; BLOOD-FLOW ; CONTRAST ; MRI ; COEFFICIENT ; PSEUDOPROGRESSION ; CURVE ; AREA
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81971594] ; National Natural Science Foundation of China[81400952] ; Natural Science Basic Research Plan in Shaanxi Province of China[2020JM325] ; Subject Boosting Project of Xijing Hospital[XJZT18ML75]
项目资助者	National Natural Science Foundation of China ; Natural Science Basic Research Plan in Shaanxi Province of China ; Subject Boosting Project of Xijing Hospital
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000536233500002
出版者	BMC
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/39519
专题	中国科学院分子影像重点实验室
通讯作者	Guo, Fan
作者单位	1.Xian Peoples Hosp, Dept Radiol, Xian, Shaanxi, Peoples R China 2.Xijing Hosp, Dept Radiol, Xian, Shaanxi, Peoples R China 3.Zhejiang Univ, Coll Biomed Engn & Instrument Sci, Dept Biomed Engn, Hangzhou, Shaanxi, Peoples R China 4.Xian Med Coll, Dept Radiol, Affliated Hosp 2, Xian, Shaanxi, Peoples R China 5.Northwest Univ, Xian Hosp 3, Dept Radiol, Affiliated Hosp, Xian, Shaanxi, Peoples R China 6.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Kang, Xiao-wei,Xi, Yi-bin,Liu, Ting-ting,et al. Grading of Glioma: combined diagnostic value of amide proton transfer weighted, arterial spin labeling and diffusion weighted magnetic resonance imaging[J]. BMC MEDICAL IMAGING,2020,20(1):8.
APA	Kang, Xiao-wei.,Xi, Yi-bin.,Liu, Ting-ting.,Wang, Ning.,Zhu, Yuan-qiang.,...&Guo, Fan.(2020).Grading of Glioma: combined diagnostic value of amide proton transfer weighted, arterial spin labeling and diffusion weighted magnetic resonance imaging.BMC MEDICAL IMAGING,20(1),8.
MLA	Kang, Xiao-wei,et al."Grading of Glioma: combined diagnostic value of amide proton transfer weighted, arterial spin labeling and diffusion weighted magnetic resonance imaging".BMC MEDICAL IMAGING 20.1(2020):8.