Investigation of the large-scale functional brain networks modulated by acupuncture

	Investigation of the large-scale functional brain networks modulated by acupuncture
	Feng, Yuanyuan 1; Bai, Lijun 1; Ren, Yanshuang 2; Wang, Hu 1; Liu, Zhenyu1 ; Zhang, Wensheng1 ; Tian, Jie 1,3
发表期刊	MAGNETIC RESONANCE IMAGING
	2011-09-01
卷号	29 期号:7 页码:958-965
文章类型	Article
摘要	Previous neuroimaging studies have primarily focused on the neural activities involving the acute effects of acupuncture. Considering that acupuncture can induce long-lasting effects, several researchers have begun to pay attention to the sustained effects of acupuncture on the resting brain. Most of these researchers adopted functional connectivity analysis based on one or a few preselected brain regions and demonstrated various function-guided brain networks underlying the specific effect of acupuncture. Few have investigated how these brain networks interacted at the whole-brain level. In this study, we sought to investigate the functional correlations throughout the entire brain following acupuncture at acupoint ST36 (ACUP) in comparison with acupuncture at nearby nonacupoint (SHAM). We divided the whole brain into 90 regions and constructed functional brain network for each condition. Then we examined the network hubs and identified statistically significant differences in functional correlations between the two conditions. Following ACUP, but not SHAM, the limbic/paralimbic regions such as the amygdala, hippocampus and anterior cingulate gyrus emerged as network hubs. For direct comparisons, increased correlations for ACUP compared to SHAM were primarily related with the limbic/paralimbic and subcortical regions such as the insula, amygdala, anterior cingulate gyrus, and thalamus, whereas decreased correlations were mainly related with the sensory and frontal cortex. The heterogeneous modulation patterns between the two conditions may relate to the functional specific modulatory effects of acupuncture. The preliminary findings may help us to better understand the long-lasting effects of acupuncture on the entire resting brain, as well as the neurophysiological mechanisms underlying acupuncture. (C) 2011 Elsevier Inc. All rights reserved.
关键词	Acupuncture Specificity Functional Correlations Functional Magnetic Resonance Imaging (Fmri) Sustained Effects
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	TOPOLOGICAL PATTERNS ; FMRI ; CONNECTIVITY ; STIMULATION ; ANALGESIA ; AMYGDALA ; DEFAULT ; PAIN ; ARCHITECTURE ; RESPONSES
收录类别	SCI
语种	英语
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000294314200009
引用统计	被引频次：46[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3955
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Chinese Acad Sci, Inst Automat, Key Lab Complex Syst & Intelligence Sci, Beijing 100190, Peoples R China 2.Guanganmen Hosp, Chinese Acad Tradit Med, Dept Radiol, Beijing 100053, Peoples R China 3.Xidian Univ, Life Sci Res Ctr, Sch Elect Engn, Xian 710071, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Feng, Yuanyuan,Bai, Lijun,Ren, Yanshuang,et al. Investigation of the large-scale functional brain networks modulated by acupuncture[J]. MAGNETIC RESONANCE IMAGING,2011,29(7):958-965.
APA	Feng, Yuanyuan.,Bai, Lijun.,Ren, Yanshuang.,Wang, Hu.,Liu, Zhenyu.,...&Tian, Jie.(2011).Investigation of the large-scale functional brain networks modulated by acupuncture.MAGNETIC RESONANCE IMAGING,29(7),958-965.
MLA	Feng, Yuanyuan,et al."Investigation of the large-scale functional brain networks modulated by acupuncture".MAGNETIC RESONANCE IMAGING 29.7(2011):958-965.

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