Source Reconstruction for Spectrally-resolved Bioluminescence Tomography with Sparse A priori Information

	Source Reconstruction for Spectrally-resolved Bioluminescence Tomography with Sparse A priori Information
	Lu, Yujie 1; Zhang, Xiaoqun 2; Douraghy, Ali 1; Stout, David 1; Tian, Jie 3; Chan, Tony F.2; Chatziioannou, Arion F.1
发表期刊	OPTICS EXPRESS
	2009-05-11
卷号	17 期号:10 页码:8062-8080
文章类型	Article
摘要	Through restoration of the light source information in small animals in vivo, optical molecular imaging, such as fluorescence molecular tomography (FMT) and bioluminescence tomography (BLT), can depict biological and physiological changes observed using molecular probes. A priori information plays an indispensable role in tomographic reconstruction. As a type of a priori information, the sparsity characteristic of the light source has not been sufficiently considered to date. In this paper, we introduce a compressed sensing method to develop a new tomographic algorithm for spectrally-resolved bioluminescence tomography. This method uses the nature of the source sparsity to improve the reconstruction quality with a regularization implementation. Based on verification of the inverse crime, the proposed algorithm is validated with Monte Carlo-based synthetic data and the popular Tikhonov regularization method. Testing with different noise levels and single/multiple source settings at different depths demonstrates the improved performance of this algorithm. Experimental reconstruction with a mouse-shaped phantom further shows the potential of the proposed algorithm. (C) 2009 Optical Society of America
关键词	Tomography Image Reconstruction Techniques Spectroscopy Fluorescence Luminescence
WOS标题词	Science & Technology ; Physical Sciences
关键词[WOS]	OPTICAL TOMOGRAPHY ; GENE-EXPRESSION ; SIMULATION ; LIGHT ; MEDIA
收录类别	SCI
语种	英语
WOS研究方向	Optics
WOS类目	Optics
WOS记录号	WOS:000266381900036
引用统计	被引频次：98[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3975
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Univ Calif Los Angeles, Crump Inst Mol Imaging, David Geffen Sch Med, Los Angeles, CA 90095 USA 2.Univ Calif Los Angeles, Dept Math, Los Angeles, CA 90095 USA 3.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing 100190, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Lu, Yujie,Zhang, Xiaoqun,Douraghy, Ali,et al. Source Reconstruction for Spectrally-resolved Bioluminescence Tomography with Sparse A priori Information[J]. OPTICS EXPRESS,2009,17(10):8062-8080.
APA	Lu, Yujie.,Zhang, Xiaoqun.,Douraghy, Ali.,Stout, David.,Tian, Jie.,...&Chatziioannou, Arion F..(2009).Source Reconstruction for Spectrally-resolved Bioluminescence Tomography with Sparse A priori Information.OPTICS EXPRESS,17(10),8062-8080.
MLA	Lu, Yujie,et al."Source Reconstruction for Spectrally-resolved Bioluminescence Tomography with Sparse A priori Information".OPTICS EXPRESS 17.10(2009):8062-8080.

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