The hybrid GLM-ICA investigation on the neural mechanism of acupoint ST36: An fMRI study

	The hybrid GLM-ICA investigation on the neural mechanism of acupoint ST36: An fMRI study
	Liu, Peng 2; Zhou, Guangyu 2; Zhang, Yi 2; Dong, Minghao 2; Qin, Wei 2; Yuan, Kai 2; Sun, Jinbo 2; Liu, Jixin 2; Liang, Jimin 2; von Deneen, Karen M.2; Liu, Yijun 3; Tian, Jie 1,2
发表期刊	NEUROSCIENCE LETTERS
	2010-08-02
卷号	479 期号:3 页码:267-271
文章类型	Article
摘要	Ample clinical reports and neuroimaging studies have demonstrated that the acupuncture has sustained effects after manipulation. However, most previous fMRI studies of acupuncture have paid little attention to this issue, only investigating on the manipulation effects. In the current study, we attempted to explore both acupuncture effects, which have positive influence to therapeutic efficiency, to reveal the neural mechanism of acupuncture. This paper combined the conventional general linear model (GLM) and independent component analysis (ICA) to study the topography and the temporal feature of brain activity to detect the brain responses to stimulation at ST36 (Zusanli) and a sham acupoint. The results showed that the manipulation-related effects and the sustained acupuncture effects separately induced statistically significant increases/decreases in the cortical-subcortical areas, including the anterior cingulate cortex (ACC), ventrolateral prefrontal cortex (VLPFC), supplementary motor area (SMA) primary/secondary somatosensory cortex (SI/SII), occipital cortices and midbrain. Our findings suggested that the analgesia effects of ST36 integrated sophisticated physiological and psychological procedures. In addition, our results have shed light on methodology in acupuncture research. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
关键词	Glm Ica Fmri Acupuncture
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	FUNCTIONAL MRI DATA ; HUMAN BRAIN ; IMPLICATED ACUPOINTS ; ACUPUNCTURE ; PAIN ; STIMULATION ; PLACEBO ; NETWORK ; CORTEX ; ACTIVATION
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000280100600019
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3984
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 2.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 3.Univ Florida, McKnight Brain Inst, Dept Psychiat & Neurosci, Gainesville, FL 32610 USA
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Liu, Peng,Zhou, Guangyu,Zhang, Yi,et al. The hybrid GLM-ICA investigation on the neural mechanism of acupoint ST36: An fMRI study[J]. NEUROSCIENCE LETTERS,2010,479(3):267-271.
APA	Liu, Peng.,Zhou, Guangyu.,Zhang, Yi.,Dong, Minghao.,Qin, Wei.,...&Tian, Jie.(2010).The hybrid GLM-ICA investigation on the neural mechanism of acupoint ST36: An fMRI study.NEUROSCIENCE LETTERS,479(3),267-271.
MLA	Liu, Peng,et al."The hybrid GLM-ICA investigation on the neural mechanism of acupoint ST36: An fMRI study".NEUROSCIENCE LETTERS 479.3(2010):267-271.

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