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The hybrid GLM-ICA investigation on the neural mechanism of acupoint ST36: An fMRI study
Liu, Peng2; Zhou, Guangyu2; Zhang, Yi2; Dong, Minghao2; Qin, Wei2; Yuan, Kai2; Sun, Jinbo2; Liu, Jixin2; Liang, Jimin2; von Deneen, Karen M.2; Liu, Yijun3; Tian, Jie1,2
Source PublicationNEUROSCIENCE LETTERS
2010-08-02
Volume479Issue:3Pages:267-271
SubtypeArticle
AbstractAmple clinical reports and neuroimaging studies have demonstrated that the acupuncture has sustained effects after manipulation. However, most previous fMRI studies of acupuncture have paid little attention to this issue, only investigating on the manipulation effects. In the current study, we attempted to explore both acupuncture effects, which have positive influence to therapeutic efficiency, to reveal the neural mechanism of acupuncture. This paper combined the conventional general linear model (GLM) and independent component analysis (ICA) to study the topography and the temporal feature of brain activity to detect the brain responses to stimulation at ST36 (Zusanli) and a sham acupoint. The results showed that the manipulation-related effects and the sustained acupuncture effects separately induced statistically significant increases/decreases in the cortical-subcortical areas, including the anterior cingulate cortex (ACC), ventrolateral prefrontal cortex (VLPFC), supplementary motor area (SMA) primary/secondary somatosensory cortex (SI/SII), occipital cortices and midbrain. Our findings suggested that the analgesia effects of ST36 integrated sophisticated physiological and psychological procedures. In addition, our results have shed light on methodology in acupuncture research. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
KeywordGlm Ica Fmri Acupuncture
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordFUNCTIONAL MRI DATA ; HUMAN BRAIN ; IMPLICATED ACUPOINTS ; ACUPUNCTURE ; PAIN ; STIMULATION ; PLACEBO ; NETWORK ; CORTEX ; ACTIVATION
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000280100600019
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3984
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
3.Univ Florida, McKnight Brain Inst, Dept Psychiat & Neurosci, Gainesville, FL 32610 USA
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Liu, Peng,Zhou, Guangyu,Zhang, Yi,et al. The hybrid GLM-ICA investigation on the neural mechanism of acupoint ST36: An fMRI study[J]. NEUROSCIENCE LETTERS,2010,479(3):267-271.
APA Liu, Peng.,Zhou, Guangyu.,Zhang, Yi.,Dong, Minghao.,Qin, Wei.,...&Tian, Jie.(2010).The hybrid GLM-ICA investigation on the neural mechanism of acupoint ST36: An fMRI study.NEUROSCIENCE LETTERS,479(3),267-271.
MLA Liu, Peng,et al."The hybrid GLM-ICA investigation on the neural mechanism of acupoint ST36: An fMRI study".NEUROSCIENCE LETTERS 479.3(2010):267-271.
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