Time-Varied Characteristics of Acupuncture Effects in fMRI Studies

	Time-Varied Characteristics of Acupuncture Effects in fMRI Studies
	Bai, Lijun 9; Qin, Wei 9; Tian, Jie 9,10; Liu, Peng 11; Li, LinLing 9; Chen, Peng12 ; Dai, Jianping 13; Craggs, Jason G.14; von Deneen, Karen M.15,16; Liu, Yijun 15,16
发表期刊	HUMAN BRAIN MAPPING
	2009-11-01
卷号	30 期号:11 页码:3445-3460
文章类型	Article
摘要	When studying the neural responses to acupuncture with a block-designed paradigm, its temporal dynamics predicted by the general linear model (GLM) conforms to typical "on-off" variations during a limited period of the experiment manipulation. Despite a lack of direct evidence associating its psychophysiological response, numerous clinical reports suggest that acupuncture can provide pain relief beyond a needling session. Therefore, a typical GLM analysis may be insensitive or inappropriate for identifying altered neural responses resulting from acupuncture. We developed a new approach to investigate the dynamics underlying sustained effects of acupuncture. Specifically, we designed two separate models to evaluate the baseline activities (prior to stimulation) and neural activities in sequential epochs, using three block-designed functional runs: acupuncture at acupoint ST36, nonmeridian point (NMP) stimulation, and a visual task. We found that the activity patterns during rest were associated with the stimulus types and that the resting activities might be even higher than that of stimulation phases. Such effects of the elevated activity during rest may reduce or eliminate the activity during stimulus conditions or even reverse the sign of brain activation using conventional GLM analysis. Moreover, such sustained responses, followed by acupuncture at ST36 and NMP, exhibited distinct patterns in wide brain structures, particularly in the limbic system and brainstem. These findings may pose great implications for the design and interpretation of a range of acupuncture neuroimaging studies. Hum Brain Mapp 30:3445-3460, 2009. (C) 2009 Wiley-Liss, Inc.
关键词	Acupuncture Resting Baseline Condition Time-varied Responses Functional Magnetic Resonance Imaging
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	INDEPENDENT COMPONENT ANALYSIS ; FUNCTIONAL MRI ; HUMAN BRAIN ; CORTICAL REPRESENTATION ; RETICULAR-FORMATION ; NEURAL MECHANISMS ; PERCEIVED PAIN ; DEFAULT MODE ; STIMULATION ; ACTIVATION
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000271565300001
引用统计	被引频次：89[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3988
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Xidian Univ, Sch Elect Engn, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing 100190, Peoples R China 3.Northeastern Univ, Sch Sinodutch Biomed & Informat Engn, Shenyang, Liaoning, Peoples R China 4.Capital Med Univ, Beijing Tradit Chinese Med Hosp, Beijing, Peoples R China 5.Capital Univ Med Sci, Beijing Tiantan Hosp, Dept Radiol, Beijing, Peoples R China 6.Univ Florida, Gainesville, FL USA 7.Univ Florida, McKnight Brain Inst, Dept Psychiat, Gainesville, FL USA 8.Univ Florida, McKnight Brain Inst, Dept Neurosci, Gainesville, FL USA 9.Xidian Univ, Sch Elect Engn, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 10.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing 100190, Peoples R China 11.Northeastern Univ, Sch Sinodutch Biomed & Informat Engn, Shenyang, Liaoning, Peoples R China 12.Capital Med Univ, Beijing Tradit Chinese Med Hosp, Beijing, Peoples R China 13.Capital Univ Med Sci, Beijing Tiantan Hosp, Dept Radiol, Beijing, Peoples R China 14.Univ Florida, Gainesville, FL USA 15.Univ Florida, McKnight Brain Inst, Dept Psychiat, Gainesville, FL USA 16.Univ Florida, McKnight Brain Inst, Dept Neurosci, Gainesville, FL USA
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Bai, Lijun,Qin, Wei,Tian, Jie,et al. Time-Varied Characteristics of Acupuncture Effects in fMRI Studies[J]. HUMAN BRAIN MAPPING,2009,30(11):3445-3460.
APA	Bai, Lijun.,Qin, Wei.,Tian, Jie.,Liu, Peng.,Li, LinLing.,...&Liu, Yijun.(2009).Time-Varied Characteristics of Acupuncture Effects in fMRI Studies.HUMAN BRAIN MAPPING,30(11),3445-3460.
MLA	Bai, Lijun,et al."Time-Varied Characteristics of Acupuncture Effects in fMRI Studies".HUMAN BRAIN MAPPING 30.11(2009):3445-3460.

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