Association ofDTNBP1With Schizophrenia: Findings From Two Independent Samples of Han Chinese Population

doi:10.3389/fpsyt.2020.00446

	Association ofDTNBP1With Schizophrenia: Findings From Two Independent Samples of Han Chinese Population
	Yang, Yongfeng 1,2,3; Zhang, Luwen 1,2,3; Guo, Dong 1,2,3; Zhang, Lin4 ; Yu, Hongyan 1; Liu, Qing1,2,3 ; Su, Xi 1,2,3; Shao, Minglong 1,2,3; Song, Men 1,2,3; Zhang, Yan 1,2,3; Ding, Minli 1; Lu, Yanli 1; Liu, Bing5,6,7 ; Li, Wenqiang 1,2,3; Yue, Weihua 8,9; Fan, Xiaoduo 10,11; Yang, Ge 1,2,3; Lv, Luxian 1,2,3,12
发表期刊	FRONTIERS IN PSYCHIATRY
ISSN	1664-0640
	2020-05-25
卷号	11 页码:9
通讯作者	Yang, Ge(yangge19800804@163.com) ; Lv, Luxian(lvx928@126.com)
摘要	Objectives Schizophrenia (SZ) is a complex psychiatric disorder that has a strong genetic basis. Dystrobrevin-binding protein 1 (DTNBP1) is one of the genes thought to be pivotal in regulating the glutamatergic system. Studies have suggested that variations inDTNBP1confer susceptibility to SZ and clinical symptoms. Here, we performed a two-stage independent verification study to identify polymorphisms of theDTNBP1gene that might be associated with SZ in the Han Chinese population. Methods In stage 1, 14 single nucleotide polymorphisms (SNPs) were genotyped in 528 paranoid SZ patients and 528 healthy controls (HCs) using the Illumina GoldenGate assays on a BeadStation 500G Genotyping System. In stage 2, ten SNPs were genotyped in an independent sample of 1,031 SZ patients and 621 HCs using the Illumina 660k Genotyping System. Clinical symptoms were assessed using the Positive and Negative Syndrome Scale. Results There was a significant association related to allele frequency, and a trend association in relation to genotype between SZ patients and HCs at rs4712253 (p= 0.03 and 0.05, respectively). These associations were not evident following Bonferroni correction (p >0.05 for both). Haplotype association analysis revealed that only two haplotypes (GAG and GAA; rs16876575-rs9464793-rs4712253) were significantly different between SZ patients and HCs (chi(2)= 4.24, 6.37,p= 0.04 and 0.01, respectively). In addition, in SZ patients there was a significant association in the rs4964793 genotype for positive symptoms, and in the rs1011313 genotype for excitement/hostility symptoms (p= 0.01 and 0.002, respectively). We found a significant association in the baseline symbol digital modalities test (SDMT), forward-digital span (DS), backward-DS, and semantic fluency between SZ patients and HCs (p <0.05 for all). Finally, the SNP rs1011313 genotypes were associated with SDMT in SZ patients (p= 0.04). Conclusion This study provides further evidence that SNP rs4712253 ofDTNBP1has a nominal association with SZ in the Han Chinese population. Such a genotype variation may play a role in psychopathology and cognitive function.
关键词	schizophrenia DTNBP1 polymorphism psychotic symptoms cognition
DOI	10.3389/fpsyt.2020.00446
关键词[WOS]	GENE DTNBP1 ; DYSBINDIN ; LOCUS ; HAPLOTYPE ; VARIANTS ; BRAIN ; RISK
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81671330] ; National Natural Science Foundation of China[81971252] ; High Scientific and Technological Research Fund of Xinxiang Medical University[2017ZDCG-04] ; National Key Research and Development Program of China[2016YFC1307001] ; Medical science and technology research project of Henan Province[2018020373] ; Science and Technology Project of Henan Province[192102310086] ; fund of Henan Clinical Research Center for Mental Disorders ; support project for the Disciplinary group of Psychology and Neuroscience, Xinxiang Medical University
项目资助者	National Natural Science Foundation of China ; High Scientific and Technological Research Fund of Xinxiang Medical University ; National Key Research and Development Program of China ; Medical science and technology research project of Henan Province ; Science and Technology Project of Henan Province ; fund of Henan Clinical Research Center for Mental Disorders ; support project for the Disciplinary group of Psychology and Neuroscience, Xinxiang Medical University
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000543203500001
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/39937
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Yang, Ge; Lv, Luxian
作者单位	1.Xinxiang Med Univ, Henan Mental Hosp, Affiliated Hosp 2, Xinxiang, Henan, Peoples R China 2.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Henan, Peoples R China 3.Huazhong Univ Sci & Technol, Affiliated Wuhan Mental Hlth Ctr, Psychiat Dept, Tongji Med Coll, Wuhan, Peoples R China 4.Huazhong Univ Sci & Technol, Affiliated Wuhan Mental Hlth Ctr, Tongji Med Coll, Wuhan, Peoples R China 5.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 7.Univ Chinese Acad Sci, Beijing, Peoples R China 8.Peking Univ, Inst Mental Hlth, Beijing, Peoples R China 9.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China 10.Univ Massachusetts, Med Sch, Psychiat Dept, Worcester, MA 01605 USA 11.UMass Mem Med Ctr, Worcester, MA USA 12.Henan Prov Peoples Hosp, Psychiat Dept, Zhengzhou, Peoples R China
推荐引用方式 GB/T 7714	Yang, Yongfeng,Zhang, Luwen,Guo, Dong,et al. Association ofDTNBP1With Schizophrenia: Findings From Two Independent Samples of Han Chinese Population[J]. FRONTIERS IN PSYCHIATRY,2020,11:9.
APA	Yang, Yongfeng.,Zhang, Luwen.,Guo, Dong.,Zhang, Lin.,Yu, Hongyan.,...&Lv, Luxian.(2020).Association ofDTNBP1With Schizophrenia: Findings From Two Independent Samples of Han Chinese Population.FRONTIERS IN PSYCHIATRY,11,9.
MLA	Yang, Yongfeng,et al."Association ofDTNBP1With Schizophrenia: Findings From Two Independent Samples of Han Chinese Population".FRONTIERS IN PSYCHIATRY 11(2020):9.