CASIA OpenIR  > 中国科学院分子影像重点实验室
Comprehensive Evaluation of the Anti-Angiogenic and Anti-Neoplastic Effects of Endostar on Liver Cancer through Optical Molecular Imaging
Zhang, Qian1,2; Du, Yang2; Xue, Zhenwen2; Chi, Chongwei2; Jia, Xiaohua2; Tian, Jie1,2
Source PublicationPLOS ONE
2014-01-08
Volume9Issue:1Pages:-
SubtypeArticle
AbstractMolecular imaging enables non-invasive monitoring of tumor growth, progression, and drug treatment response, and it has become an important tool to promote biological studies in recent years. In this study, we comprehensively evaluated the in vivo anti-angiogenic and anti-neoplastic effects of Endostar on liver cancer based on the optical molecular imaging systems including micro-computer tomography (Micro-CT), bioluminescence molecular imaging (BLI) and fluorescence molecular tomography (FMT). Firefly luciferase (fLuc) and green fluorescent protein (GFP) dual labeled human hepatocellular carcinoma cells (HCC-LM3-fLuc-GFP cells) were used to establish the subcutaneous and orthotopic liver tumor model. After the tumor cells were implanted 14 similar to 18 days, Endostar (5 mg/kg/day) was administered through an intravenous tail vein injection for continuous 14 days. The computer tomography angiography (CTA) and BLI were carried out for the subcutaneous tumor model. FMT was executed for the orthotopic tumor model. The CTA data showed that tumor vessel formation and the peritumoral vasculature of subcutaneous tumor in the Endostar treatment group was significantly inhibited compared to the control group. The BLI data exhibited the obvious tumor inhibition day 8 post-treatment. The FMT detected the tumor suppression effects of Endostar as early as day 4 post-treatment and measured the tumor location. The above data confirmed the effects of Endostar on anti-angiogenesis and tumor suppression on liver cancer. Our system combined CTA, BLI, and FMT to offer more comprehensive information about the effects of Endostar on the suppression of vessel and tumor formation. Optical molecular imaging system enabled the non-invasive and reliable assessment of anti-tumor drug efficacy on liver cancer.
WOS HeadingsScience & Technology
WOS KeywordHEPATOCELLULAR-CARCINOMA ; TUMOR ANGIOGENESIS ; ORTHOTOPIC MODELS ; METASTASIS ; GROWTH ; THERAPY ; MICE
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000329862500257
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3998
Collection中国科学院分子影像重点实验室
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Qian,Du, Yang,Xue, Zhenwen,et al. Comprehensive Evaluation of the Anti-Angiogenic and Anti-Neoplastic Effects of Endostar on Liver Cancer through Optical Molecular Imaging[J]. PLOS ONE,2014,9(1):-.
APA Zhang, Qian,Du, Yang,Xue, Zhenwen,Chi, Chongwei,Jia, Xiaohua,&Tian, Jie.(2014).Comprehensive Evaluation of the Anti-Angiogenic and Anti-Neoplastic Effects of Endostar on Liver Cancer through Optical Molecular Imaging.PLOS ONE,9(1),-.
MLA Zhang, Qian,et al."Comprehensive Evaluation of the Anti-Angiogenic and Anti-Neoplastic Effects of Endostar on Liver Cancer through Optical Molecular Imaging".PLOS ONE 9.1(2014):-.
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