Use of Indocyanine Green for Detecting the Sentinel Lymph Node in Breast Cancer Patients: From Preclinical Evaluation to Clinical Validation

	Use of Indocyanine Green for Detecting the Sentinel Lymph Node in Breast Cancer Patients: From Preclinical Evaluation to Clinical Validation
	Chi, Chongwei1 ; Ye, Jinzuo1 ; Ding, Haolong 2; He, De 2; Huang, Wenhe 2; Zhang, Guo-Jun 2; Tian, Jie 1
发表期刊	PLOS ONE
	2013-12-16
卷号	8 期号:12 页码:-
文章类型	Article
摘要	Assessment of the sentinel lymph node (SLN) in patients with early stage breast cancer is vital in selecting the appropriate surgical approach. However, the existing methods, including methylene blue and nuclides, possess low efficiency and effectiveness in mapping SLNs, and to a certain extent exert side effects during application. Indocyanine green (ICG), as a fluorescent dye, has been proved reliable usage in SLN detection by several other groups. In this paper, we introduce a novel surgical navigation system to detect SLN with ICG. This system contains two charge-coupled devices (CCD) to simultaneously capture real-time color and fluorescent video images through two different bands. During surgery, surgeons only need to follow the fluorescence display. In addition, the system saves data automatically during surgery enabling surgeons to find the registration point easily according to image recognition algorithms. To test our system, 5 mice and 10 rabbits were used for the preclinical setting and 22 breast cancer patients were utilized for the clinical evaluation in our experiments. The detection rate was 100% and an average of 2.7 SLNs was found in 22 patients. Our results show that the usage of our surgical navigation system with ICG to detect SLNs in breast cancer patients is technically feasible.
关键词	From Preclinical Clinical Validation
WOS标题词	Science & Technology
关键词[WOS]	NEAR-INFRARED FLUORESCENCE ; CELL-PENETRATING PEPTIDES ; BIOPSY ; TRIAL ; SURGERY ; DYE ; IDENTIFICATION ; DISSECTION ; TRANSLATION ; ANGIOGRAPHY
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000328735700144
引用统计	被引频次：58[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/3999
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Chinese Acad Sci, Inst Automat, Intelligent Med Res Ctr, Beijing, Peoples R China 2.Shantou Univ, Coll Med, Canc Hosp, Breast Ctr, Shantou, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Chi, Chongwei,Ye, Jinzuo,Ding, Haolong,et al. Use of Indocyanine Green for Detecting the Sentinel Lymph Node in Breast Cancer Patients: From Preclinical Evaluation to Clinical Validation[J]. PLOS ONE,2013,8(12):-.
APA	Chi, Chongwei.,Ye, Jinzuo.,Ding, Haolong.,He, De.,Huang, Wenhe.,...&Tian, Jie.(2013).Use of Indocyanine Green for Detecting the Sentinel Lymph Node in Breast Cancer Patients: From Preclinical Evaluation to Clinical Validation.PLOS ONE,8(12),-.
MLA	Chi, Chongwei,et al."Use of Indocyanine Green for Detecting the Sentinel Lymph Node in Breast Cancer Patients: From Preclinical Evaluation to Clinical Validation".PLOS ONE 8.12(2013):-.

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