CASIA OpenIR  > 中国科学院分子影像重点实验室
Use of Indocyanine Green for Detecting the Sentinel Lymph Node in Breast Cancer Patients: From Preclinical Evaluation to Clinical Validation
Chi, Chongwei1; Ye, Jinzuo1; Ding, Haolong2; He, De2; Huang, Wenhe2; Zhang, Guo-Jun2; Tian, Jie1
Source PublicationPLOS ONE
2013-12-16
Volume8Issue:12Pages:-
SubtypeArticle
AbstractAssessment of the sentinel lymph node (SLN) in patients with early stage breast cancer is vital in selecting the appropriate surgical approach. However, the existing methods, including methylene blue and nuclides, possess low efficiency and effectiveness in mapping SLNs, and to a certain extent exert side effects during application. Indocyanine green (ICG), as a fluorescent dye, has been proved reliable usage in SLN detection by several other groups. In this paper, we introduce a novel surgical navigation system to detect SLN with ICG. This system contains two charge-coupled devices (CCD) to simultaneously capture real-time color and fluorescent video images through two different bands. During surgery, surgeons only need to follow the fluorescence display. In addition, the system saves data automatically during surgery enabling surgeons to find the registration point easily according to image recognition algorithms. To test our system, 5 mice and 10 rabbits were used for the preclinical setting and 22 breast cancer patients were utilized for the clinical evaluation in our experiments. The detection rate was 100% and an average of 2.7 SLNs was found in 22 patients. Our results show that the usage of our surgical navigation system with ICG to detect SLNs in breast cancer patients is technically feasible.
KeywordFrom Preclinical Clinical Validation
WOS HeadingsScience & Technology
WOS KeywordNEAR-INFRARED FLUORESCENCE ; CELL-PENETRATING PEPTIDES ; BIOPSY ; TRIAL ; SURGERY ; DYE ; IDENTIFICATION ; DISSECTION ; TRANSLATION ; ANGIOGRAPHY
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000328735700144
Citation statistics
Cited Times:43[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/3999
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Chinese Acad Sci, Inst Automat, Intelligent Med Res Ctr, Beijing, Peoples R China
2.Shantou Univ, Coll Med, Canc Hosp, Breast Ctr, Shantou, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Chi, Chongwei,Ye, Jinzuo,Ding, Haolong,et al. Use of Indocyanine Green for Detecting the Sentinel Lymph Node in Breast Cancer Patients: From Preclinical Evaluation to Clinical Validation[J]. PLOS ONE,2013,8(12):-.
APA Chi, Chongwei.,Ye, Jinzuo.,Ding, Haolong.,He, De.,Huang, Wenhe.,...&Tian, Jie.(2013).Use of Indocyanine Green for Detecting the Sentinel Lymph Node in Breast Cancer Patients: From Preclinical Evaluation to Clinical Validation.PLOS ONE,8(12),-.
MLA Chi, Chongwei,et al."Use of Indocyanine Green for Detecting the Sentinel Lymph Node in Breast Cancer Patients: From Preclinical Evaluation to Clinical Validation".PLOS ONE 8.12(2013):-.
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