Amplitude of Low Frequency Fluctuation Abnormalities in Adolescents with Online Gaming Addiction

	Amplitude of Low Frequency Fluctuation Abnormalities in Adolescents with Online Gaming Addiction
	Yuan, Kai 1; Jin, Chenwang 2; Cheng, Ping 1; Yang, Xuejuan 1; Dong, Tao 1; Bi, Yanzhi 1; Xing, Lihong 1; von Deneen, Karen M.1; Yu, Dahua 1,3; Liu, Junyu 4; Liang, Jun 4; Cheng, Tingting 4; Qin, Wei 1; Tian, Jie 1,5
发表期刊	PLOS ONE
	2013-11-04
卷号	8 期号:11 页码:-
文章类型	Article
摘要	The majority of previous neuroimaging studies have demonstrated both structural and task-related functional abnormalities in adolescents with online gaming addiction (OGA). However, few functional magnetic resonance imaging (fMRI) studies focused on the regional intensity of spontaneous fluctuations in blood oxygen level-dependent (BOLD) during the resting state and fewer studies investigated the relationship between the abnormal resting-state properties and the impaired cognitive control ability. In the present study, we employed the amplitude of low frequency fluctuation (ALFF) method to explore the local features of spontaneous brain activity in adolescents with OGA and healthy controls during resting-state. Eighteen adolescents with OGA and 18 age-, education-and gender-matched healthy volunteers participated in this study. Compared with healthy controls, adolescents with OGA showed a significant increase in ALFF values in the left medial orbitofrontal cortex (OFC), the left precuneus, the left supplementary motor area (SMA), the right parahippocampal gyrus (PHG) and the bilateral middle cingulate cortex (MCC). The abnormalities of these regions were also detected in previous addiction studies. More importantly, we found that ALFF values of the left medial OFC and left precuneus were positively correlated with the duration of OGA in adolescents with OGA. The ALFF values of the left medial OFC were also correlated with the color-word Stroop test performance. Our results suggested that the abnormal spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology of OGA.
关键词	Gyrus Cinguli Parahippocampal Gyrus Prefrontal Cortex Magnetic Resonance
WOS标题词	Science & Technology
关键词[WOS]	INTERNET ADDICTION ; REGIONAL HOMOGENEITY ; STROOP TASK ; BRAIN ; CORTEX ; AREAS
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000326503400085
引用统计	被引频次：51[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4000
专题	中国科学院分子影像重点实验室
通讯作者	Yuan, Kai
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Xian, Peoples R China 2.Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Med Imaging, Xian 710049, Shaanxi, Peoples R China 3.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Informat Proc Lab, Baotou, Inner Mongolia, Peoples R China 4.Baotou Heping Middle Sch, Baotou, Inner Mongolia, Peoples R China 5.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Kai,Jin, Chenwang,Cheng, Ping,et al. Amplitude of Low Frequency Fluctuation Abnormalities in Adolescents with Online Gaming Addiction[J]. PLOS ONE,2013,8(11):-.
APA	Yuan, Kai.,Jin, Chenwang.,Cheng, Ping.,Yang, Xuejuan.,Dong, Tao.,...&Tian, Jie.(2013).Amplitude of Low Frequency Fluctuation Abnormalities in Adolescents with Online Gaming Addiction.PLOS ONE,8(11),-.
MLA	Yuan, Kai,et al."Amplitude of Low Frequency Fluctuation Abnormalities in Adolescents with Online Gaming Addiction".PLOS ONE 8.11(2013):-.

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