Assessing Cue-Induced Brain Response as a Function of Abstinence Duration in Heroin-Dependent Individuals: An Event-Related fMRI Study

	Assessing Cue-Induced Brain Response as a Function of Abstinence Duration in Heroin-Dependent Individuals: An Event-Related fMRI Study
	Li, Qiang1 ; Wang, Yarong 1; Zhang, Yi 2; Li, Wei1 ; Zhu, Jia 1; Zheng, Ying 1; Chen, Jiajie 1; Zhao, Liyan 3; Zhou, Zhenyu 5; Liu, Yijun 4,5; Wang, Wei 1; Tian, Jie 1,2,6
发表期刊	PLOS ONE
	2013-05-07
卷号	8 期号:5 页码:-
文章类型	Article
摘要	The brain activity induced by heroin-related cues may play a role in the maintenance of heroin dependence. Whether the reinforcement or processing biases construct an everlasting feature of heroin addiction remains to be resolved. We used an event-related fMRI paradigm to measure brain activation in response to heroin cue-related pictures versus neutral pictures as the control condition in heroin-dependent patients undergoing short-term and long-term abstinence. The self-reported craving scores were significantly increased after cue exposure in the short-term abstinent patients (t = 3.000, P = 0.008), but no increase was found in the long-term abstinent patients (t = 1.510, P = 0.149). However, no significant differences in cue-induced craving changes were found between the two groups (t = 1.193, P = 0.850). Comparing between the long-term abstinence and short-term abstinence groups, significant decreases in brain activation were detected in the bilateral anterior cingulated cortex, left medial prefrontal cortex, caudate, middle occipital gyrus, inferior parietal lobule and right precuneus. Among all of the heroin dependent patients, the abstinence duration was negatively correlated with brain activation in the left medial prefrontal cortex and left inferior parietal lobule. These findings suggest that long-term abstinence may be useful for heroin-dependent patients to diminish their saliency value of heroin-related cues and possibly lower the relapse vulnerability to some extent.
关键词	Event-related Fmri Study
WOS标题词	Science & Technology
关键词[WOS]	MEDIAL FRONTAL-CORTEX ; NEURAL RESPONSES ; MOTOR IMAGERY ; SMOKING CUES ; ADDICTION ; WITHDRAWAL ; TIME ; ORGANIZATION ; CONSUMPTION ; DYSFUNCTION
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000319654700080
引用统计	被引频次：31[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4007
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Fourth Mil Med Univ, Dept Radiol, Tangdu Hosp, Xian 710032, Peoples R China 2.Xidian Univ, Life Sci Res Ctr, Sch Life Sci & Technol, Xian, Peoples R China 3.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China 4.Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32611 USA 5.Peking Univ, Coll Engn, Beijing 100871, Peoples R China 6.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Li, Qiang,Wang, Yarong,Zhang, Yi,et al. Assessing Cue-Induced Brain Response as a Function of Abstinence Duration in Heroin-Dependent Individuals: An Event-Related fMRI Study[J]. PLOS ONE,2013,8(5):-.
APA	Li, Qiang.,Wang, Yarong.,Zhang, Yi.,Li, Wei.,Zhu, Jia.,...&Tian, Jie.(2013).Assessing Cue-Induced Brain Response as a Function of Abstinence Duration in Heroin-Dependent Individuals: An Event-Related fMRI Study.PLOS ONE,8(5),-.
MLA	Li, Qiang,et al."Assessing Cue-Induced Brain Response as a Function of Abstinence Duration in Heroin-Dependent Individuals: An Event-Related fMRI Study".PLOS ONE 8.5(2013):-.

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