A common variant in OXTR rs53576 impacts topological patterns of brain functional networks

doi:10.1007/s00787-019-01414-5

	A common variant in OXTR rs53576 impacts topological patterns of brain functional networks
	Wang, Junping 1; Zhang, Yan 1; Zhu, Dan 1; Yang, Zonghe 1; Liu, Feng 1; Qin, Wen 1; Zhu, Jiajia 1; Liu, Bing2 ; Jiang, Tianzi2 ; Yu, Chunshui 1,3
发表期刊	EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
ISSN	1018-8827
	2020-07-01
卷号	29 期号:7 页码:993-1002
通讯作者	Wang, Junping(wangjunping_tj@163.com) ; Liu, Feng(fengliu@tijmu.edu.cn)
摘要	A common variant (rs53576, G/A) in the oxytocin receptor (OXTR) gene is associated with individual differences in social behavior and may increase the risk for neuropsychiatric disorders characterized by social impairment, especially autism. Although recent functional magnetic resonance imaging (fMRI) studies have identified functional connectivity alteration in some brain regions in risk A allele carriers, it is currently unknown whether this dysfunctional connectivity causes disruption of the topological properties of brain functional networks. We applied a graph-theoretical analysis to investigate the topological properties of brain networks derived from resting-state fMRI in relation to AA homozygotes versus G allele carriers in 290 cognitive normal young adults. We found both AA homozygotes and G allele carriers demonstrated small-world properties; however, male AA homozygotes showed lower normalized clustering coefficient, small-worldness, and local efficiency compared with male G allele carriers, no differences survived after Bonferroni correction; and the inter-group differences of all three metrics exhibited an allele-load-dependent trend (AA < AG < GG), indicating a randomization shift of their brain functional networks. No significant results were observed in any global measures in female AA homozygotes as compared to female G allele carriers. Our results suggested that the topological patterns of brain functional networks were altered in OXTR rs53576 male homozygotes for the risk A allele compared with male G allele carriers, providing evidence for the disruption of integrity in large-scale intrinsic brain networks in a sex-dimorphic manner.
关键词	Oxytocin receptor gene Resting-state functional magnetic resonance imaging Small-world network Graphtheoretical analysis
DOI	10.1007/s00787-019-01414-5
关键词[WOS]	RECEPTOR GENE OXTR ; SEX-DIFFERENCES ; CONNECTIVITY NETWORKS ; POLYMORPHISM OXTR ; GLOBAL SIGNAL ; OXYTOCIN ; AUTISM ; ASSOCIATION ; VASOPRESSIN ; CONNECTOME
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of China[81871431] ; Natural Science Foundation of China[81301201] ; Natural Science Foundation of China[81271551] ; Natural Science Foundation of Tianjin Municipal Science and Technology Commission[18JCYBJC26300] ; Natural Science Foundation of Tianjin Municipal Science and Technology Commission[18JCQNJC10900] ; New Century Talent Training Project of Tianjin Medical University General Hospital
项目资助者	Natural Science Foundation of China ; Natural Science Foundation of Tianjin Municipal Science and Technology Commission ; New Century Talent Training Project of Tianjin Medical University General Hospital
WOS研究方向	Psychology ; Pediatrics ; Psychiatry
WOS类目	Psychology, Developmental ; Pediatrics ; Psychiatry
WOS记录号	WOS:000549381100002
出版者	SPRINGER
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/40168
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Wang, Junping; Liu, Feng
作者单位	1.Tianjin Med Univ, Dept Radiol, Gen Hosp, 154 Anshan Rd, Tianjin 300052, Peoples R China 2.Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit Inst Automat, Beijing 100190, Peoples R China 3.Tianjin Med Univ, Sch Med Imaging, Tianjin 300052, Peoples R China
推荐引用方式 GB/T 7714	Wang, Junping,Zhang, Yan,Zhu, Dan,et al. A common variant in OXTR rs53576 impacts topological patterns of brain functional networks[J]. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY,2020,29(7):993-1002.
APA	Wang, Junping.,Zhang, Yan.,Zhu, Dan.,Yang, Zonghe.,Liu, Feng.,...&Yu, Chunshui.(2020).A common variant in OXTR rs53576 impacts topological patterns of brain functional networks.EUROPEAN CHILD & ADOLESCENT PSYCHIATRY,29(7),993-1002.
MLA	Wang, Junping,et al."A common variant in OXTR rs53576 impacts topological patterns of brain functional networks".EUROPEAN CHILD & ADOLESCENT PSYCHIATRY 29.7(2020):993-1002.