CASIA OpenIR  > 中国科学院分子影像重点实验室
Precise visual distinction of brain glioma from normal tissues via targeted photoacoustic and fluorescence navigation
Jia, Xiaohua1,2; Fan, Kelong3; Zhang, Ruofei3,8; Zhang, Dan4; Zhang, Jianjun5; Gao, Yuan2; Zhang, Tao6; Li, Wanjun7; Li, Junlai1; Yan, Xiyun3,8; Tian, Jie2,8,9
Source PublicationNANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
ISSN1549-9634
2020-07-01
Volume27Pages:9
Corresponding AuthorLi, Junlai(Li_jl@yeah.net) ; Yan, Xiyun(yanxy@ibp.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
AbstractThe vexing difficulty in distinguishing glioma from normal tissues is a major obstacle to prognosis. In an attempt to solve this problem, we used a joint strategy that combined targeted-cancer stem cells nanoparticles with precise photoacoustic and fluorescence navigation. We showed that traditional magnetic resonance imaging (MRI) did not represent the true morphology of tumors. Targeted nanoparticles specifically accumulated in the tumor area. Glioma was precisely revealed at the cellular level. Tumors could be non-invasively detected through the intact skull by fluorescence molecular imaging (FMI) and photoacoustic tomography (PAT). Moreover, PAT can be used to excise deep gliomas. Histological correlation confirmed that FMI imaging accurately delineated scattered tumor cells. The combination of optical PAT and FMI navigation fulfilled the promise of precise visual imaging in glioma detection and resection. This detection method was deeper and more intuitive than the current intraoperative pathology. (C) 2020 The Author(s). Published by Elsevier Inc.
KeywordGlioma Molecular imaging Transferrin receptor 1 Nanoparticles
DOI10.1016/j.nano.2020.102204
WOS KeywordIMAGING BIOMARKERS ; TOMOGRAPHY ; NEUROONCOLOGY ; NANOPARTICLES ; DIAGNOSIS ; RESECTION ; ATLAS ; CELLS
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2017YFA0700401] ; National Key Research and Development Program of China[2016YFA0100902] ; National Key Research and Development Program of China[2016YFA0201401] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81701771] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81771835] ; National Natural Science Foundation of China[31530026] ; National Natural Science Foundation of China[31900981] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[YJKYYQ20180048] ; Chinese Academy of Sciences[QYZDY-SSW-SMC013] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; Beijing Municipal Science & Technology Commission[Z161100002616022] ; Beijing Municipal Science & Technology Commission[Z171100000117023] ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program[19JCZDJC65300] ; Strategic Priority Research Program[XDA09030306] ; Strategic Priority Research Program[XDB29040101] ; Strategic Priority Research Program[XDPB0304]
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Beijing Municipal Science & Technology Commission ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program ; Strategic Priority Research Program
WOS Research AreaScience & Technology - Other Topics ; Research & Experimental Medicine
WOS SubjectNanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS IDWOS:000549858200009
PublisherELSEVIER
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/40176
Collection中国科学院分子影像重点实验室
Corresponding AuthorLi, Junlai; Yan, Xiyun; Tian, Jie
Affiliation1.Gen Hosp Peoples Liberat Army, Dept Ultrasound, Beijing, Peoples R China
2.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Biophys, CAS Engn Lab Nanozyme, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China
4.Tsinghua Univ, Ctr Biomed Anal, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
6.Hubei Univ Med, Taihe Hosp, Dept Neurosurg, Shiyan, Hubei, Peoples R China
7.Xi An Jiao Tong Univ, Dept Pathol, Affiliated Hosp 3201, Hanzhong, Shaanxi, Peoples R China
8.Univ Chinese Acad Sci, Beijing, Peoples R China
9.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Jia, Xiaohua,Fan, Kelong,Zhang, Ruofei,et al. Precise visual distinction of brain glioma from normal tissues via targeted photoacoustic and fluorescence navigation[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2020,27:9.
APA Jia, Xiaohua.,Fan, Kelong.,Zhang, Ruofei.,Zhang, Dan.,Zhang, Jianjun.,...&Tian, Jie.(2020).Precise visual distinction of brain glioma from normal tissues via targeted photoacoustic and fluorescence navigation.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,27,9.
MLA Jia, Xiaohua,et al."Precise visual distinction of brain glioma from normal tissues via targeted photoacoustic and fluorescence navigation".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 27(2020):9.
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