Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke | |
Wu, Di1,2,3,4; Fu, Yongjuan5; Wu, Longfei1,2; Huber, Mitchell6; Chen, Jian7; Yao, Tianqi1,2; Zhang, Mo8; Wu, Chuanjie1,2; Song, Ming9; He, Xiaoduo1,2; Li, Sijie3; Zhang, Yongbiao10; Li, Shengli11; Ding, Yuchuan6; Ji, Xunming1,2,3,4 | |
发表期刊 | NEUROTHERAPEUTICS |
ISSN | 1933-7213 |
2020-07-24 | |
页码 | 9 |
通讯作者 | Ji, Xunming(jixm@ccmu.edu.cn) |
摘要 | Early reperfusion is increasingly prioritized in ischemic stroke care, but outcomes remain suboptimal. Therefore, there is an urgent need to find neuroprotective approaches that can be combined with reperfusion to maximize efficacy. Here, the neuroprotective mechanisms behind therapeutic hypothermia were evaluated in a monkey model of ischemic stroke. Focal ischemia was induced in adult rhesus monkeys by placing autologous clots in the middle cerebral artery. Monkeys were treated with tissue plasminogen activator (t-PA) alone or t-PA plus selective intra-arterial cooling (SI-AC). Serial MRI scans and functional deficit were evaluated after ischemia. Histopathology and immunohistochemistry analysis were performed after the final MRI scan. t-PA plus SI-AC treatment led to a higher rate of MRI tissue rescue, and significantly improved neurologic deficits and daily activity scores compared with t-PA alone. In peri-infarct areas, higher fractional anisotropy values and greater fiber numbers were observed in models receiving t-PA plus SI-AC. Histological findings indicated that myelin damage, spheroids, and spongiosis were significantly ameliorated in models receiving SI-AC treatment. White matter integrity was also improved by SI-AC based on immunochemical staining. Our study demonstrates that SI-AC can be effectively combined with t-PA to improve both structural and functional recovery in a monkey model of focal ischemia. These findings provide proof-of-concept that it may be feasible to add neuroprotective agents as adjunctive treatments to reperfusion therapy for stroke. |
关键词 | Stroke recovery hypothermia white matter diffusion tensor imaging rhesus monkey |
DOI | 10.1007/s13311-020-00895-6 |
关键词[WOS] | ACUTE ISCHEMIC-STROKE ; DIFFUSION ; NEUROPROTECTION ; HYPOTHERMIA ; TRANSIENT ; INFUSION ; INJURY ; MRI |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[81871022] ; National Natural Science Foundation of China[81771260] ; National Natural Science Foundation of China[81620108011] ; National Key R&D Program of China[2017YFC1308401] ; mission talent project of Beijing Municipal Administration of Hospitals[SML20150802] ; Beijing Municipal Science and Technology Project[Z181100001918026] ; Beijing Municipal Administration of Hospitals' Youth Programme[QML20170802] |
项目资助者 | National Natural Science Foundation of China ; National Key R&D Program of China ; mission talent project of Beijing Municipal Administration of Hospitals ; Beijing Municipal Science and Technology Project ; Beijing Municipal Administration of Hospitals' Youth Programme |
WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
WOS类目 | Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy |
WOS记录号 | WOS:000552159300001 |
出版者 | SPRINGER |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/40202 |
专题 | 脑网络组研究 |
通讯作者 | Ji, Xunming |
作者单位 | 1.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China 2.Capital Med Univ, Xuanwu Hosp, China Amer Inst Neurosci, Beijing 100053, Peoples R China 3.Beijing Key Lab Hypoxia Conditioning Translat Med, Beijing, Peoples R China 4.Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China 5.Capital Med Univ, Xuanwu Hosp, Dept Pathol, Beijing 100053, Peoples R China 6.Wayne State Univ, Sch Med, Dept Neurosurg, Detroit, MI USA 7.Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing 100053, Peoples R China 8.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 9.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 10.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Biol Sci & Med Engn, Interdisciplinary Innovat Inst Med & Engn, Beijing, Peoples R China 11.Capital Med Univ, Dept Lab Anim Sci, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Wu, Di,Fu, Yongjuan,Wu, Longfei,et al. Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke[J]. NEUROTHERAPEUTICS,2020:9. |
APA | Wu, Di.,Fu, Yongjuan.,Wu, Longfei.,Huber, Mitchell.,Chen, Jian.,...&Ji, Xunming.(2020).Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke.NEUROTHERAPEUTICS,9. |
MLA | Wu, Di,et al."Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke".NEUROTHERAPEUTICS (2020):9. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论