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DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy
Zhang, Qian1,2,3; Jiang, Qiao4; Li, Na4; Dai, Luru4; Liu, Qing4; Song, Linlin4; Wang, Jinye4; Li, Yaqian3; Tian, Jie1,2,3; Ding, Baoquan4; Du, Yang3
Source PublicationACS NANO
AbstractMany chemotherapeutics used for cancer treatments encounter issues during delivery to tumors in vivo and may have high levels of systemic toxicity due to their nonspecific distribution. Various materials have been explored to fabricate nanoparticles as drug carriers to Improve delivery efficiency. However, most of these materials suffer from multiple drawbacks, such as limited biocompatibility and inability to engineer spatially addressable surfaces that can be utilized for multifunctional activity. Here, we demonstrate that DNA origami possessed enhanced tumor passive targeting and long-lasting properties at the tumor region. Particularly, the triangle-shaped DNA origami exhibits optimal tumor passive targeting accumulation. The delivery of the known anticancer drug doxorubicin into tumors by self-assembled DNA origami nanostructures was performed, and this approach showed prominent therapeutic efficacy in vivo. The DNA origami carriers were prepared through the self-assembly of M13mp18 phage DNA and hundreds of complementary DNA helper strands; the doxorubicin was subsequently noncovalently intercalated into these nanostructures. After conducting fluorescence imaging and safety evaluation, the doxorubicin-containing DNA origami exhibited remarkable antitumor efficacy without observable systemic toxicity in nude mice bearing orthotopic breast tumors labeled with green fluorescent protein. Our results demonstrated the potential of DNA origami nanostructures as innovative platforms for the efficient and safe drug delivery of cancer therapeutics in vivo.
KeywordDna Origami Doxorubicin In Vivo Delivery Cancer Therapy Fluorescence Imaging
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
Indexed BySCI
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000339463100017
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Cited Times:190[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China
2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Natl Ctr NanoSci & Technol, Beijing 100190, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Qian,Jiang, Qiao,Li, Na,et al. DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy[J]. ACS NANO,2014,8(7):6633-6643.
APA Zhang, Qian.,Jiang, Qiao.,Li, Na.,Dai, Luru.,Liu, Qing.,...&Du, Yang.(2014).DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy.ACS NANO,8(7),6633-6643.
MLA Zhang, Qian,et al."DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy".ACS NANO 8.7(2014):6633-6643.
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