MIR137polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex | |
Liu, Shu1,2; Li, Ang1,2; Liu, Yong1,2,3; Li, Jin1,2; Wang, Meng1,2; Sun, Yuqing1,2; Qin, Wen4; Yu, Chunshui4; Jiang, Tianzi1,2,3,5,6; Liu, Bing1,2,3 | |
发表期刊 | PSYCHOLOGICAL MEDICINE |
ISSN | 0033-2917 |
2020-07-01 | |
卷号 | 50期号:9页码:1510-1518 |
摘要 | Background Genome-wide association studies (GWAS) have consistently revealed that a variant of microRNA 137 (MIR137) shows a quite significant association with schizophrenia. Identifying the network of genes regulated byMIR137could provide insights into the biological processes underlying schizophrenia. In addition, DLPFC functional connectivity, a robust correlate ofMIR137,may provide plausible endophenotypes. However, the regulatory role of theMIR137gene network in the disrupted functional connectivity remains unclear. Here, we tested the effects of theMIR137regulated genes on the risk for schizophrenia and DLPFC functional connectivity. Methods To evaluate the additive effects of theMIR137regulated genes (N= 1274), we calculated aMIR137polygenic risk score (PRS) for schizophrenia and tested its association with the risk for schizophrenia in the genomic data of a Han Chinese population that included schizophrenia patients (N= 589) and normal controls (N= 575). We then investigated the association betweenMIR137PRS and DLPFC functional connectivity in two independent young healthy cohorts (N= 356 andN= 314). Results We found that theMIR137PRS successfully captured the differences in genetic structure between the patients and controls, but the single geneMIR137did not. We then consistently found that a higherMIR137PRS was correlated with lower functional connectivities between the DLPFC and both the superior parietal cortex and the inferior temporal cortex in two independent cohorts. Conclusion The findings suggested that these two functional connectivities of the DLPFC could be important endophenotypes linking theMIR137-regulated genetic structure to schizophrenia. |
关键词 | Dorsolateral prefrontal cortex functional connectivity microRNA-137 polygenic risk score schizophrenia |
DOI | 10.1017/S0033291719001442 |
关键词[WOS] | WORKING-MEMORY ; FRONTOPARIETAL ACTIVITY ; MIR-137 ; GENE ; MIR137 ; SUSCEPTIBILITY ; POPULATION ; NETWORKS ; MODULATION ; RS1625579 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Key Research and Development Plan[2016YFC0904300] ; Strategic Priority Research Program of Chinese Academy of Science[XDBS01020200] ; Natural Science Foundation of China[81771451] ; Natural Science Foundation of China[31300934] |
项目资助者 | National Key Research and Development Plan ; Strategic Priority Research Program of Chinese Academy of Science ; Natural Science Foundation of China |
WOS研究方向 | Psychology ; Psychiatry |
WOS类目 | Psychology, Clinical ; Psychiatry ; Psychology |
WOS记录号 | WOS:000553814400010 |
出版者 | CAMBRIDGE UNIV PRESS |
七大方向——子方向分类 | 脑网络分析 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/40257 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
通讯作者 | Liu, Bing |
作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr & Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China 4.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia |
第一作者单位 | 模式识别国家重点实验室 |
通讯作者单位 | 模式识别国家重点实验室; 中国科学院自动化研究所 |
推荐引用方式 GB/T 7714 | Liu, Shu,Li, Ang,Liu, Yong,et al. MIR137polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex[J]. PSYCHOLOGICAL MEDICINE,2020,50(9):1510-1518. |
APA | Liu, Shu.,Li, Ang.,Liu, Yong.,Li, Jin.,Wang, Meng.,...&Liu, Bing.(2020).MIR137polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex.PSYCHOLOGICAL MEDICINE,50(9),1510-1518. |
MLA | Liu, Shu,et al."MIR137polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex".PSYCHOLOGICAL MEDICINE 50.9(2020):1510-1518. |
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