CASIA OpenIR  > 脑网络组研究
MIR137polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex
Liu, Shu1,2; Li, Ang1,2; Liu, Yong1,2,3; Li, Jin1,2; Wang, Meng1,2; Sun, Yuqing1,2; Qin, Wen4; Yu, Chunshui4; Jiang, Tianzi1,2,3,5,6; Liu, Bing1,2,3
Source PublicationPSYCHOLOGICAL MEDICINE
ISSN0033-2917
2020-07-01
Volume50Issue:9Pages:1510-1518
Abstract

Background Genome-wide association studies (GWAS) have consistently revealed that a variant of microRNA 137 (MIR137) shows a quite significant association with schizophrenia. Identifying the network of genes regulated byMIR137could provide insights into the biological processes underlying schizophrenia. In addition, DLPFC functional connectivity, a robust correlate ofMIR137,may provide plausible endophenotypes. However, the regulatory role of theMIR137gene network in the disrupted functional connectivity remains unclear. Here, we tested the effects of theMIR137regulated genes on the risk for schizophrenia and DLPFC functional connectivity. Methods To evaluate the additive effects of theMIR137regulated genes (N= 1274), we calculated aMIR137polygenic risk score (PRS) for schizophrenia and tested its association with the risk for schizophrenia in the genomic data of a Han Chinese population that included schizophrenia patients (N= 589) and normal controls (N= 575). We then investigated the association betweenMIR137PRS and DLPFC functional connectivity in two independent young healthy cohorts (N= 356 andN= 314). Results We found that theMIR137PRS successfully captured the differences in genetic structure between the patients and controls, but the single geneMIR137did not. We then consistently found that a higherMIR137PRS was correlated with lower functional connectivities between the DLPFC and both the superior parietal cortex and the inferior temporal cortex in two independent cohorts. Conclusion The findings suggested that these two functional connectivities of the DLPFC could be important endophenotypes linking theMIR137-regulated genetic structure to schizophrenia.

KeywordDorsolateral prefrontal cortex functional connectivity microRNA-137 polygenic risk score schizophrenia
DOI10.1017/S0033291719001442
WOS KeywordWORKING-MEMORY ; FRONTOPARIETAL ACTIVITY ; MIR-137 ; GENE ; MIR137 ; SUSCEPTIBILITY ; POPULATION ; NETWORKS ; MODULATION ; RS1625579
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Plan[2016YFC0904300] ; Strategic Priority Research Program of Chinese Academy of Science[XDBS01020200] ; Natural Science Foundation of China[81771451] ; Natural Science Foundation of China[31300934]
Funding OrganizationNational Key Research and Development Plan ; Strategic Priority Research Program of Chinese Academy of Science ; Natural Science Foundation of China
WOS Research AreaPsychology ; Psychiatry
WOS SubjectPsychology, Clinical ; Psychiatry ; Psychology
WOS IDWOS:000553814400010
PublisherCAMBRIDGE UNIV PRESS
Sub direction classification脑网络分析
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/40257
Collection脑网络组研究
Corresponding AuthorLiu, Bing
Affiliation1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr & Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
4.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
First Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Corresponding Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China;  Institute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Liu, Shu,Li, Ang,Liu, Yong,et al. MIR137polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex[J]. PSYCHOLOGICAL MEDICINE,2020,50(9):1510-1518.
APA Liu, Shu.,Li, Ang.,Liu, Yong.,Li, Jin.,Wang, Meng.,...&Liu, Bing.(2020).MIR137polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex.PSYCHOLOGICAL MEDICINE,50(9),1510-1518.
MLA Liu, Shu,et al."MIR137polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex".PSYCHOLOGICAL MEDICINE 50.9(2020):1510-1518.
Files in This Item: Download All
File Name/Size DocType Version Access License
liu2019 (3).pdf(517KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Liu, Shu]'s Articles
[Li, Ang]'s Articles
[Liu, Yong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liu, Shu]'s Articles
[Li, Ang]'s Articles
[Liu, Yong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liu, Shu]'s Articles
[Li, Ang]'s Articles
[Liu, Yong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: liu2019 (3).pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.