CASIA OpenIR  > 中国科学院分子影像重点实验室
Multilevel, hybrid regularization method for reconstruction of fluorescent molecular tomography
Yi, Huangjian1; Chen, Duofang1; Qu, Xiaochao1; Peng, Kuan1; Chen, Xueli1; Zhou, Yuanyuan1; Tian, Jie1,2; Liang, Jimin1
Source PublicationAPPLIED OPTICS
2012-03-01
Volume51Issue:7Pages:975-986
SubtypeArticle
AbstractIn this paper, a multilevel, hybrid regularization method is presented for fluorescent molecular tomography (FMT) based on the hp-finite element method (hp-FEM) with a continuous wave. The hybrid regularization method combines sparsity regularization and Landweber iterative regularization to improve the stability of the solution of the ill-posed inverse problem. In the first coarse mesh level, considering the fact that the fluorescent probes are sparsely distributed in the entire reconstruction region in most FMT applications, the sparse regularization method is employed to take full advantage of this sparsity. In the subsequent refined mesh levels, since the reconstruction region is reduced and the initial value of the unknown parameters is provided from the previous mesh, these mesh levels seem to be different from the first level. As a result, the Landweber iterative regularization method is applied for reconstruction. Simulation experiments on a 3D digital mouse atlas and physical experiments on a phantom are conducted to evaluate the performance of our method. The reconstructed results show the potential and feasibility of the proposed approach. (C) 2012 Optical Society of America
KeywordAnimals Mice Tomography Algorithms
WOS HeadingsScience & Technology ; Physical Sciences
WOS KeywordDIFFUSE OPTICAL TOMOGRAPHY ; FINITE-ELEMENT-METHOD ; BIOLUMINESCENCE TOMOGRAPHY ; ALGORITHM ; SYSTEM ; APPROXIMATION ; FEASIBILITY ; LIGHT
Indexed BySCI
Language英语
WOS Research AreaOptics
WOS SubjectOptics
WOS IDWOS:000301190000054
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4030
Collection中国科学院分子影像重点实验室
Corresponding AuthorLiang, Jimin
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Yi, Huangjian,Chen, Duofang,Qu, Xiaochao,et al. Multilevel, hybrid regularization method for reconstruction of fluorescent molecular tomography[J]. APPLIED OPTICS,2012,51(7):975-986.
APA Yi, Huangjian.,Chen, Duofang.,Qu, Xiaochao.,Peng, Kuan.,Chen, Xueli.,...&Liang, Jimin.(2012).Multilevel, hybrid regularization method for reconstruction of fluorescent molecular tomography.APPLIED OPTICS,51(7),975-986.
MLA Yi, Huangjian,et al."Multilevel, hybrid regularization method for reconstruction of fluorescent molecular tomography".APPLIED OPTICS 51.7(2012):975-986.
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