Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| Multilevel, hybrid regularization method for reconstruction of fluorescent molecular tomography | |
| Yi, Huangjian1; Chen, Duofang1; Qu, Xiaochao1; Peng, Kuan1; Chen, Xueli1; Zhou, Yuanyuan1; Tian, Jie1,2; Liang, Jimin1 | |
| 发表期刊 | APPLIED OPTICS
 |
| 2012-03-01 | |
| 卷号 | 51期号:7页码:975-986 |
| 文章类型 | Article |
| 摘要 | In this paper, a multilevel, hybrid regularization method is presented for fluorescent molecular tomography (FMT) based on the hp-finite element method (hp-FEM) with a continuous wave. The hybrid regularization method combines sparsity regularization and Landweber iterative regularization to improve the stability of the solution of the ill-posed inverse problem. In the first coarse mesh level, considering the fact that the fluorescent probes are sparsely distributed in the entire reconstruction region in most FMT applications, the sparse regularization method is employed to take full advantage of this sparsity. In the subsequent refined mesh levels, since the reconstruction region is reduced and the initial value of the unknown parameters is provided from the previous mesh, these mesh levels seem to be different from the first level. As a result, the Landweber iterative regularization method is applied for reconstruction. Simulation experiments on a 3D digital mouse atlas and physical experiments on a phantom are conducted to evaluate the performance of our method. The reconstructed results show the potential and feasibility of the proposed approach. (C) 2012 Optical Society of America |
| 关键词 | Animals Mice Tomography Algorithms |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 关键词[WOS] | DIFFUSE OPTICAL TOMOGRAPHY ; FINITE-ELEMENT-METHOD ; BIOLUMINESCENCE TOMOGRAPHY ; ALGORITHM ; SYSTEM ; APPROXIMATION ; FEASIBILITY ; LIGHT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Optics |
| WOS类目 | Optics |
| WOS记录号 | WOS:000301190000054 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/4030 |
| 专题 | 中国科学院分子影像重点实验室 |
| 通讯作者 | Liang, Jimin |
| 作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yi, Huangjian,Chen, Duofang,Qu, Xiaochao,et al. Multilevel, hybrid regularization method for reconstruction of fluorescent molecular tomography[J]. APPLIED OPTICS,2012,51(7):975-986. |
| APA | Yi, Huangjian.,Chen, Duofang.,Qu, Xiaochao.,Peng, Kuan.,Chen, Xueli.,...&Liang, Jimin.(2012).Multilevel, hybrid regularization method for reconstruction of fluorescent molecular tomography.APPLIED OPTICS,51(7),975-986. |
| MLA | Yi, Huangjian,et al."Multilevel, hybrid regularization method for reconstruction of fluorescent molecular tomography".APPLIED OPTICS 51.7(2012):975-986. |
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| 1000003729153.pdf（1376KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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