Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| In Vivo Gastric Cancer Targeting and Imaging Using Novel Symmetric Cyanine Dye-Conjugated GX1 Peptide Probes | |
| Xin, Jing1; Zhang, Xianghan1; Liang, Jimin1; Xia, Limin3; Yin, Jipeng3; Nie, Yongzhan3; Wu, Kaichun3; Tian, Jie1,2 | |
| 发表期刊 | BIOCONJUGATE CHEMISTRY
 |
| 2013-07-01 | |
| 卷号 | 24期号:7页码:1134-1143 |
| 文章类型 | Article |
| 摘要 | To facilitate the translation of cancer fluorescence imaging into clinical practice, the development of stable and highly specific and sensitive targeted fluorescence probes with low toxicity is desirable. GX1, a gastric tumor angiogenesis marker candidate, holds promise in the target-specific delivery of molecular imaging probes for early gastric cancer detection in vivo. In this study, we describe the design and synthesis of a series of novel penta-methine cyanine dyes using the symmetric synthesis method and further conjugated the dyes with GX1, allowing specific binding to the vasculature of gastric cancer. This efficient synthetic route can decrease the undesired byproducts, while increasing yield. Furthermore, in vivo fluorescence imaging revealed that this novel targeted probe accumulates selectively in the tumor site of SGC-7901 subcutaneous xenograft models. The combination of such novel vasculature-targeted molecular probes with fluorescence imaging technology may improve early detection, metastasis detection, and antitumor angiogenesis therapy for gastric cancer. |
| 关键词 | Symmetric |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 关键词[WOS] | SPECTRAL PROPERTIES ; ANGIOGENESIS ; VASCULATURE ; DNA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| WOS类目 | Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic |
| WOS记录号 | WOS:000322103200002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/4031 |
| 专题 | 中国科学院分子影像重点实验室 |
| 通讯作者 | Tian, Jie |
| 作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 3.Fourth Mil Med Univ, Inst Digest Dis, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China |
| 通讯作者单位 | 中国科学院自动化研究所 |
| 推荐引用方式 GB/T 7714 | Xin, Jing,Zhang, Xianghan,Liang, Jimin,et al. In Vivo Gastric Cancer Targeting and Imaging Using Novel Symmetric Cyanine Dye-Conjugated GX1 Peptide Probes[J]. BIOCONJUGATE CHEMISTRY,2013,24(7):1134-1143. |
| APA | Xin, Jing.,Zhang, Xianghan.,Liang, Jimin.,Xia, Limin.,Yin, Jipeng.,...&Tian, Jie.(2013).In Vivo Gastric Cancer Targeting and Imaging Using Novel Symmetric Cyanine Dye-Conjugated GX1 Peptide Probes.BIOCONJUGATE CHEMISTRY,24(7),1134-1143. |
| MLA | Xin, Jing,et al."In Vivo Gastric Cancer Targeting and Imaging Using Novel Symmetric Cyanine Dye-Conjugated GX1 Peptide Probes".BIOCONJUGATE CHEMISTRY 24.7(2013):1134-1143. |
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| 149.Bioconjugate Che（4380KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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