CASIA OpenIR  > 中国科学院分子影像重点实验室
Encapsulating tantalum oxide into polypyrrole nanoparticles for X-ray CT/photoacoustic bimodal imaging-guided photothermal ablation of cancer
Jin, Yushen1; Li, Yanyan1; Ma, Xibo3; Zha, Zhengbao1; Shi, Liangliang3; Tian, Jie3; Dai, Zhifei2
Source PublicationBIOMATERIALS
2014
Volume35Issue:22Pages:5795-5804
SubtypeArticle
AbstractA nanotheranostic agent has been readily fabricated by encapsulating tantalum oxide (TaOx) nanoparticles (NPs) into polypyrrole (PPy) NPs via a facile one-step chemical oxidation polymerization for bimodal imaging guided photothermal ablation of tumor. It was proved that the obtained composite nanoparticles (TaOx@PPy NPs) with an average diameter around 45 nm could operate as an efficient bimodal contrast agent to simultaneously enhance X-ray CT and photoacoustic (PA) imaging greatly in vivo. Systemically administered TaOx@PPy NPs could passively accumulate at the tumor site during the blood circulation, which was proved by both CT and PA imaging. In addition, the in vivo therapeutic examinations showed that TaOx@PPy NPs exhibited significant photothermal cytotoxicity under near infrared laser irradiation. The tumor growth inhibition was evaluated to be 66.5% for intravenously injection and 100% for intratumoral injection, respectively. This versatile agent can be developed as a smart and promising nanoplatform that integrates multiple capabilities for both accurate diagnosing and precise locating of cancerous tissue, as well as effective photoablation of tumor. (C) 2014 Elsevier Ltd. All rights reserved.
KeywordPhotothermal Therapy Photoacoustic Imaging Cf Imaging Polypyrrole Tantalum Oxide Nanoparticle
WOS HeadingsScience & Technology ; Technology
WOS KeywordSENTINEL LYMPH-NODE ; COMPUTED-TOMOGRAPHY ; GOLD NANOCAGES ; MAGNETIC-RESONANCE ; PHOTOACOUSTIC TOMOGRAPHY ; CARBON NANOTUBES ; GRAPHENE OXIDE ; THERAPY ; ULTRASOUND ; NANORODS
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000336694700016
Citation statistics
Cited Times:97[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4032
Collection中国科学院分子影像重点实验室
Corresponding AuthorDai, Zhifei
Affiliation1.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China
2.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Jin, Yushen,Li, Yanyan,Ma, Xibo,et al. Encapsulating tantalum oxide into polypyrrole nanoparticles for X-ray CT/photoacoustic bimodal imaging-guided photothermal ablation of cancer[J]. BIOMATERIALS,2014,35(22):5795-5804.
APA Jin, Yushen.,Li, Yanyan.,Ma, Xibo.,Zha, Zhengbao.,Shi, Liangliang.,...&Dai, Zhifei.(2014).Encapsulating tantalum oxide into polypyrrole nanoparticles for X-ray CT/photoacoustic bimodal imaging-guided photothermal ablation of cancer.BIOMATERIALS,35(22),5795-5804.
MLA Jin, Yushen,et al."Encapsulating tantalum oxide into polypyrrole nanoparticles for X-ray CT/photoacoustic bimodal imaging-guided photothermal ablation of cancer".BIOMATERIALS 35.22(2014):5795-5804.
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