CASIA OpenIR  > 脑网络组研究
NR4A1 Methylation Associated Multimodal Neuroimaging Patterns Impaired in Temporal Lobe Epilepsy
Zhi, Dongmei1,2,3; Wu, Wenyue4,5; Xiao, Bo4; Qi, Shile6; Jiang, Rongtao1,2,3; Yang, Xingdong7; Yang, Jian8; Xiao, Wenbiao4; Liu, Chaorong4; Long, Hongyu4; Calhoun, Vince D.6; Long, Lili4; Sui, Jing1,2,3,6,9
Source PublicationFRONTIERS IN NEUROSCIENCE
2020-07-14
Volume14Issue:727Pages:10
Abstract

DNA hypermethylation has been widely observed in temporal lobe epilepsy (TLE), in which NR4A1 knockdown has been reported to be able to alleviate seizure severity in mouse model, while the underlying methylation-imaging pathway modulated by aberrant methylation levels of NR4A1 remains to be clarified in patients with TLE. Here, using multi-site canonical correlation analysis with reference, methylation levels of NR4A1 in blood were used as priori to guide fusion of three MRI features: functional connectivity (FC), fractional anisotropy (FA), and gray matter volume (GMV) for 56 TLE patients and 65 healthy controls. Post-hoc correlations were further evaluated between the identified NR4A1-associated brain components and disease onset. Results suggested that higher NR4A1 methylation levels in TLE were related with impaired temporal-cerebellar and occipital-cerebellar FC strength, lower FA in cingulum (hippocampus), and reduced GMV in putamen, temporal pole, and cerebellum. Moreover, findings were also replicated well in both patient subsets with either right TLE or left TLE only. Particularly, right TLE patients showed poorer cognitive abilities and more severe brain impairment than left TLE patients, especially more reduced GMV in thalamus. In summary, this work revealed a potential imaging-methylation pathway modulated by higher NR4A1 methylation in TLE via data mining, which may impact the above-mentioned multimodal brain circuits and was also associated with earlier disease onset and more cognitive deficits.

Keywordtemporal lobe epilepsy multimodal fusion functional connectivity fractional anisotropy gray matter volume
DOI10.3389/fnins.2020.00727
WOS KeywordWHITE-MATTER ABNORMALITIES ; VOXEL-BASED MORPHOMETRY ; EPIGENETIC MECHANISMS ; CEREBELLAR ATROPHY ; SEIZURE ONSET ; THALAMUS ; EXPRESSION ; SCLEROSIS ; DURATION ; BRAIN
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation[61773380] ; National Natural Science Foundation[81671300] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32040100] ; Beijing Municipal Science and Technology Commission[Z181100001518005] ; Key Research Project of the Chinese Ministry of Science and Technology[2016YFC0904400] ; Clinical Research Foundation of Xiangya Hospital[2016L08] ; National Institute of Health[1R01MH117107] ; National Institute of Health[P20GM103472]
Funding OrganizationNational Natural Science Foundation ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Beijing Municipal Science and Technology Commission ; Key Research Project of the Chinese Ministry of Science and Technology ; Clinical Research Foundation of Xiangya Hospital ; National Institute of Health
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000556758900001
PublisherFRONTIERS MEDIA SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/40357
Collection脑网络组研究
Corresponding AuthorLong, Lili; Sui, Jing
Affiliation1.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha, Peoples R China
5.Nanchang Univ, Affiliated Hosp 2, Dept Neurol, Nanchang, Jiangxi, Peoples R China
6.Emory Univ, Georgia State Univ, Georgia Inst Technol, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30322 USA
7.Beijing Haidian Hosp, Dept Neurol, Beijing, Peoples R China
8.Beijing Inst Technol, Sch Opt & Elect, Beijing Engn Res Ctr Mixed Real & Adv Display, Beijing, Peoples R China
9.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Corresponding Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhi, Dongmei,Wu, Wenyue,Xiao, Bo,et al. NR4A1 Methylation Associated Multimodal Neuroimaging Patterns Impaired in Temporal Lobe Epilepsy[J]. FRONTIERS IN NEUROSCIENCE,2020,14(727):10.
APA Zhi, Dongmei.,Wu, Wenyue.,Xiao, Bo.,Qi, Shile.,Jiang, Rongtao.,...&Sui, Jing.(2020).NR4A1 Methylation Associated Multimodal Neuroimaging Patterns Impaired in Temporal Lobe Epilepsy.FRONTIERS IN NEUROSCIENCE,14(727),10.
MLA Zhi, Dongmei,et al."NR4A1 Methylation Associated Multimodal Neuroimaging Patterns Impaired in Temporal Lobe Epilepsy".FRONTIERS IN NEUROSCIENCE 14.727(2020):10.
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