Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| Probability method for Cerenkov luminescence tomography based on conformance error minimization | |
Ding, Xintao1,2; Wang, Kun3 ; Jie, Biao2; Luo, Yonglong2; Hu, Zhenhua3; Tian, Jie3
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| 发表期刊 | BIOMEDICAL OPTICS EXPRESS
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| 2014-07-01 | |
| 卷号 | 5期号:7页码:2091-2112 |
| 文章类型 | Article |
| 摘要 | Cerenkov luminescence tomography (CLT) was developed to reconstruct a three-dimensional (3D) distribution of radioactive probes inside a living animal. Reconstruction methods are generally performed within a unique framework by searching for the optimum solution. However, the ill-posed aspect of the inverse problem usually results in the reconstruction being non-robust. In addition, the reconstructed result may not match reality since the difference between the highest and lowest uptakes of the resulting radiotracers may be considerably large, therefore the biological significance is lost. In this paper, based on the minimization of a conformance error, a probability method is proposed that consists of qualitative and quantitative modules. The proposed method first pinpoints the organ that contains the light source. Next, we developed a 0-1 linear optimization subject to a space constraint to model the CLT inverse problem, which was transformed into a forward problem by employing a region growing method to solve the optimization. After running through all of the elements used to grow the sources, a source sequence was obtained. Finally, the probability of each discrete node being the light source inside the organ was reconstructed. One numerical study and two in vivo experiments were conducted to verify the performance of the proposed algorithm, and comparisons were carried out using the hp-finite element method (hp-FEM). The results suggested that our proposed probability method was more robust and reasonable than hp-FEM. (C) 2014 Optical Society of America |
| 关键词 | - |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 关键词[WOS] | POSITRON-EMITTING RADIOTRACERS ; BIOLUMINESCENCE TOMOGRAPHY ; FLUORESCENCE TOMOGRAPHY ; RECONSTRUCTION METHOD ; OPTICAL-PROPERTIES ; CONDITION NUMBERS ; INVERSE PROBLEMS ; RADIATION ; LIGHT ; MODEL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS记录号 | WOS:000338929100009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/4035 |
| 专题 | 中国科学院分子影像重点实验室 |
| 通讯作者 | Hu, Zhenhua |
| 作者单位 | 1.Anhui Normal Univ, Sch Terr Resources & Tourism, Wuhu 241003, Anhui, Peoples R China 2.Anhui Normal Univ, Sch Math & Comp Sci, Wuhu 241003, Anhui, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| 通讯作者单位 | 中国科学院自动化研究所 |
| 推荐引用方式 GB/T 7714 | Ding, Xintao,Wang, Kun,Jie, Biao,et al. Probability method for Cerenkov luminescence tomography based on conformance error minimization[J]. BIOMEDICAL OPTICS EXPRESS,2014,5(7):2091-2112. |
| APA | Ding, Xintao,Wang, Kun,Jie, Biao,Luo, Yonglong,Hu, Zhenhua,&Tian, Jie.(2014).Probability method for Cerenkov luminescence tomography based on conformance error minimization.BIOMEDICAL OPTICS EXPRESS,5(7),2091-2112. |
| MLA | Ding, Xintao,et al."Probability method for Cerenkov luminescence tomography based on conformance error minimization".BIOMEDICAL OPTICS EXPRESS 5.7(2014):2091-2112. |
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| Probability method f（595KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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